Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development

Kevin G Bath; Scott J Russo; Kristen E Pleil; Eric S Wohleb; Ronald S Duman; Jason J Radley

doi:10.1016/j.ynstr.2017.05.001

Back

Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development

Journal article

Open access

Peer reviewed

Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development

Kevin G Bath, Scott J Russo, Kristen E Pleil, Eric S Wohleb, Ronald S Duman and Jason J Radley

Neurobiology of stress, Vol.7, pp.137-151

12/01/2017

DOI: 10.1016/j.ynstr.2017.05.001

PMCID: PMC5736942

PMID: 29276735

Files and links (1)

url

https://doi.org/10.1016/j.ynstr.2017.05.001View

Published (Version of record) Open Access

Abstract

The current review is meant to synthesize research presented as part of a symposium at the 2016 Neurobiology of Stress workshop in Irvine California. The focus of the symposium was “Stress and the Synapse: New Concepts and Methods” and featured the work of several junior investigators. The presentations focused on the impact of various forms of stress (altered maternal care, binge alcohol drinking, chronic social defeat, and chronic unpredictable stress) on synaptic function, neurodevelopment, and behavioral outcomes. One of the goals of the symposium was to highlight the mechanisms accounting for how the nervous system responds to stress and their impact on outcome measures with converging effects on the development of pathological behavior. Dr. Kevin Bath's presentation focused on the impact of disruptions in early maternal care and its impact on the timing of hippocampus maturation in mice, finding that this form of stress drove accelerated synaptic and behavioral maturation, and contributed to the later emergence of risk for cognitive and emotional disturbance. Dr. Scott Russo highlighted the impact of chronic social defeat stress in adolescent mice on the development and plasticity of reward circuity, with a focus on glutamatergic development in the nucleus accumbens and mesolimbic dopamine system, and the implications of these changes for disruptions in social and hedonic response, key processes disturbed in depressive pathology. Dr. Kristen Pleil described synaptic changes in the bed nuclei of the stria terminalis that underlie the behavioral consequences of allostatic load produced by repeated cycles of alcohol binge drinking and withdrawal. Dr. Eric Wohleb and Dr. Ron Duman provided new data associating decreased mammalian target of rapamycin (mTOR) signaling and neurobiological changes in the synapses in response to chronic unpredictable stress, and highlighted the potential for the novel antidepressant ketamine to rescue synaptic and behavioral effects. In aggregate, these presentations showcased how divergent perspectives provide new insights into the ways in which stress impacts circuit development and function, with implications for understanding emergence of affective pathology.

Early-life stress

Neuropeptide Y

Susceptibility

Corticotropin-releasing factor

Prefrtonal cortex

Major depressive disorder

Resilience

Nucleus accumbens

Mammalian target of rapamycin

Special Section on

Bed nuclei of the stria terminalis

Stress Workshop 2016 Guest Edited by Terrence Deak

Hippocampus

Details

Title: Subtitle: Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development
Creators: Kevin G Bath - Department of Cognitive Linguistic and Psychological Sciences, Brown University, Providence, RI 02912, United States
Scott J Russo - Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Kristen E Pleil - Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, United States
Eric S Wohleb - Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45237, United States
Ronald S Duman - Department of Psychiatry, Yale School of Medicine, New Haven, CT 06508, United States
Jason J Radley - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Neurobiology of stress, Vol.7, pp.137-151
DOI: 10.1016/j.ynstr.2017.05.001
PMID: 29276735
PMCID: PMC5736942
NLM abbreviation: Neurobiol Stress
ISSN: 2352-2895
eISSN: 2352-2895
Publisher: Elsevier
Grant note: name: NIH IDeA Networks of Biomedical Research Excellence, award: P20GM103430, R01 MH090264, R01 MH104559, P50AT008661-01; DOI: 10.13039/100000002, name: NIH, award: K99AA023559, F32AA021043; DOI: 10.13039/100000002, name: NIH, award: R37MH045481, R01MH093897; name: state of Connecticut; DOI: 10.13039/100000002, name: NIH, award: R01MH095972
Language: English
Date published: 12/01/2017
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070111702771

Metrics

14 Record Views

43 Times Cited - Web of Science