Journal article
Circulating Adipokines and Inflammatory Markers and Postmenopausal Breast Cancer Risk
JNCI : Journal of the National Cancer Institute, Vol.107(9), djv169
09/2015
DOI: 10.1093/jnci/djv169
PMCID: PMC4651104
PMID: 26185195
Abstract
Adipokines and inflammation may provide a mechanistic link between obesity and postmenopausal breast cancer, yet epidemiologic data on their associations with breast cancer risk are limited.
In a case-cohort analysis nested within the Women's Health Initiative Observational Study, a prospective cohort of postmenopausal women, baseline plasma samples from 875 incident breast cancer case patients and 839 subcohort participants were tested for levels of seven adipokines, namely leptin, adiponectin, resistin, interleukin-6, tumor necrosis factor-α, hepatocyte growth factor, and plasminogen activator inhibitor-1, and for C-reactive protein (CRP), an inflammatory marker. Data were analyzed by multivariable Cox modeling that included established breast cancer risk factors and previously measured estradiol and insulin levels. All statistical tests were two-sided.
The association between plasma CRP levels and breast cancer risk was dependent on hormone therapy (HT) use at baseline (P interaction = .003). In a model that controlled for multiple breast cancer risk factors including body mass index (BMI), estradiol, and insulin, CRP level was positively associated with breast cancer risk among HT nonusers (hazard ratio for high vs low CRP levels = 1.67, 95% confidence interval = 1.04 to 2.68, P trend = .029). None of the other adipokines were statistically significantly associated with breast cancer risk. Following inclusion of CRP, insulin, and estradiol in a multivariable model, the association of BMI with breast cancer was attenuated by 115%.
These data indicate that CRP is a risk factor for postmenopausal breast cancer among HT nonusers. Inflammatory mediators, together with insulin and estrogen, may play a role in the obesity-breast cancer relation.
Details
- Title: Subtitle
- Circulating Adipokines and Inflammatory Markers and Postmenopausal Breast Cancer Risk
- Creators
- Marc J Gunter - Imperial College LondonTao Wang - Albert Einstein College of MedicineMary Cushman - University of VermontXiaonan Xue - Albert Einstein College of MedicineSylvia Wassertheil-Smoller - Albert Einstein College of MedicineHoward D Strickler - Albert Einstein College of MedicineThomas E Rohan - Albert Einstein College of MedicineJoAnn E Manson - Harvard Medical SchoolAnne McTiernan - Fred Hutch Cancer CenterRobert C Kaplan - Albert Einstein College of MedicinePhilipp E Scherer - The University of Texas Southwestern Medical CenterRowan T Chlebowski - University of California, Los AngelesLinda Snetselaar - University of IowaDan Wang - Albert Einstein College of MedicineGloria Y F Ho - Albert Einstein College of Medicine
- Resource Type
- Journal article
- Publication Details
- JNCI : Journal of the National Cancer Institute, Vol.107(9), djv169
- Publisher
- United States
- DOI
- 10.1093/jnci/djv169
- PMID
- 26185195
- PMCID
- PMC4651104
- ISSN
- 1460-2105
- eISSN
- 1460-2105
- Grant note
- HHSN268201100046C / PHS HHS HHSN268201100004C / PHS HHS P30 CA015704 / NCI NIH HHS UL1 TR001073 / NCATS NIH HHS HHSN268201100002C / PHS HHS HHSN271201100004C / PHS HHS N01WH74310 / WHI NIH HHS HHSN268201100001C / PHS HHS HHSN268201100003C / PHS HHS P30 CA013330 / NCI NIH HHS
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983996094002771
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