Journal article
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis
Cell metabolism, Vol.37(5), pp.1223-1234.e5
05/06/2025
DOI: 10.1016/j.cmet.2025.03.017
PMID: 40267913
Abstract
Excessive intake of dietary fructose increases the risk of metabolic-dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and cancers. However, what host factors determine disease vulnerability is incompletely understood. Here, we leverage genetically divergent mouse strains, mass spectrometry-based metabolomics, and in vivo isotope tracing, identifying circulating glycerate as a biomarker that predicts resilience to fructose-induced hepatic steatosis in both sexes. We found that the surge of circulating glycerate after an oral fructose provision reflects strong small-intestinal fructose catabolism. Such fructose clearance by the small intestine is linked to a weaker induction of hepatic de novo lipogenesis and steatosis upon chronic fructose exposure across strains. These data indicate the potential utility of an oral fructose tolerance test and circulating glycerate measurements to predict an individual's susceptibility to fructose-elicited steatotic liver and provide personalized dietary recommendations.
Details
- Title: Subtitle
- Circulating glycerate predicts resilience to fructose-induced hepatic steatosis
- Creators
- Cuauhtemoc B Ramirez - University of California, IrvineIn Sook Ahn - University of California, Los AngelesVarvara I Rubtsova - University of California, IrvineIngrid Cely - University of California, Los AngelesJohnny Le - University of California, IrvineJoohwan Kim - University of California, IrvineSunhee Jung - University of California, IrvineMiranda E Kelly - University of California, IrvineYeojin Kim - University of California, IrvineHosung Bae - University of California, IrvineWon-Suk Song - University of California, IrvineYasmine H Alam - University of California, IrvineGuanglin Zhang - University of California, Los AngelesGraciel Diamante - University of California, Los AngelesAlina Chao - University of California, IrvineLauren Hoffner - University of California, IrvineAlexis Anica - University of California, IrvineIzabelle Le - University of California, IrvineMiranda L Lopez - University of California, IrvineIan J Tamburini - University of California, IrvineElena M Moyer - University of California, IrvineAriel Tsai - University of California, IrvineQin Yang - University of California, IrvineXing Dai - University of California, IrvineDaniele Piomelli - University of California, IrvineGina Lee - University of California, IrvineXia Yang - University of California, Los AngelesCholsoon Jang - University of California, Irvine
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.37(5), pp.1223-1234.e5
- DOI
- 10.1016/j.cmet.2025.03.017
- PMID
- 40267913
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Grant note
- T32 CA009054 / NCI NIH HHS R01 DK117850 / NIDDK NIH HHS R01 AA029124 / NIAAA NIH HHS R35 GM145307 / NIGMS NIH HHS K22 CA234399 / NCI NIH HHS R21 AA030358 / NIAAA NIH HHS R01 DK104363 / NIDDK NIH HHS F31 DK134173 / NIDDK NIH HHS
- Language
- English
- Date published
- 05/06/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985217131902771
Metrics
1 Record Views