Citalopram for continuation therapy after repetitive transcranial magnetic stimulation in vascular depression

Robert G Robinson; Veselin Tenev; Ricardo E Jorge

doi:10.1097/JGP.0b013e3181a88423

Back

Citalopram for continuation therapy after repetitive transcranial magnetic stimulation in vascular depression

Journal article

Peer reviewed

Citalopram for continuation therapy after repetitive transcranial magnetic stimulation in vascular depression

Robert G Robinson, Veselin Tenev and Ricardo E Jorge

The American journal of geriatric psychiatry, Vol.17(8), pp.682-687

08/2009

DOI: 10.1097/JGP.0b013e3181a88423

PMCID: PMC2758492

PMID: 19625785

Files and links (1)

url

http://doi.org/10.1097/JGP.0b013e3181a88423View

Open Access

Abstract

The authors previously reported that repetitive transcranial magnetic stimulation (rTMS) produced a response rate of 39.4% among 62 patients with treatment resistant vascular depression. This study was undertaken to assess the outcome of continuation therapy to prevent relapse among these patients during 9 weeks after completion of rTMS. Patients were randomly assigned to 18,000 pulses of rTMS given over 3 weeks or sham treatment using double blind methods. After rTMS, all patients were given 20 mg/day of citalopram for 9 weeks and reevaluated at 3, 6, and 9 weeks. Outpatient continuation treatment trial. Patients with vascular depression (N = 62), as determined by magnetic resonance imaging hyperintensities and three or more clinical risk factors for vascular disease without other major medical illness, were recruited. They had onset of major depression after age 50 and failed at least one trial of antidepressants. After rTMS or sham treatment, all treatment responders were given citalopram for 9 weeks. Among the 33 patients who were given rTMS, 13 responded (i.e., >50% decline in Hamilton Depression Scale score). Of these 13, all completed the 9 weeks of continuation treatment. There were nine patients who continued to be responders and four who had a relapse of depression. More effective methods are needed to treat elderly patients with treatment resistant vascular depression and to prevent relapse among treatment responders.

Depressive Disorder, Major - etiology

Humans

Middle Aged

Depressive Disorder, Major - therapy

Male

Treatment Outcome

Secondary Prevention

Transcranial Magnetic Stimulation - methods

Activities of Daily Living

Antidepressive Agents - therapeutic use

Depressive Disorder, Major - psychology

Magnetic Resonance Imaging

Cerebrovascular Disorders - complications

Statistics, Nonparametric

Citalopram - therapeutic use

Female

Aged

Details

Title: Subtitle: Citalopram for continuation therapy after repetitive transcranial magnetic stimulation in vascular depression
Creators: Robert G Robinson - Department of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA. robert-robinson@uiowa.edu
Veselin Tenev
Ricardo E Jorge
Resource Type: Journal article
Publication Details: The American journal of geriatric psychiatry, Vol.17(8), pp.682-687
DOI: 10.1097/JGP.0b013e3181a88423
PMID: 19625785
PMCID: PMC2758492
NLM abbreviation: Am J Geriatr Psychiatry
ISSN: 1064-7481
eISSN: 1545-7214
Publisher: England
Grant note: R01 MH063405-03 / NIMH NIH HHS R01 MH065134-03 / NIMH NIH HHS R01 MH063405-01A1 / NIMH NIH HHS R01 MH063405-05 / NIMH NIH HHS R01 MH 063405 / NIMH NIH HHS R01 MH065134 / NIMH NIH HHS R01 MH065134-04 / NIMH NIH HHS R01 MH063405-02 / NIMH NIH HHS R01 MH063405 / NIMH NIH HHS R01 MH065134-02 / NIMH NIH HHS R01 MH065134-01A1 / NIMH NIH HHS R01 MH063405-04 / NIMH NIH HHS R01 MH065134-05 / NIMH NIH HHS
Language: English
Date published: 08/2009
Academic Unit: Psychiatry
Record Identifier: 9984003453702771

Metrics

28 Record Views

8 Times Cited - Web of Science