Journal article
Citramalic acid in cerebrospinal fluid of patients with bacterial meningitis
Clinical chemistry, Vol.30(7), pp.1209-1212
07/1984
DOI: 10.1093/clinchem/30.7.1209
PMID: 6145530
Abstract
Cerebrospinal fluid (CSF) from uninfected patients and from patients with bacterial and viral meningitis was analyzed by gas-liquid chromatography, with use of a flame ionization detector, and by gas chromatography-mass spectrometry. The resulting profiles were consistent and reproducible. Hydroxy acids were the compounds found in greatest abundance in both normal and infected CSF. Control experiments to establish the sensitivity and efficiency of the extraction and derivatization methods are also presented. Constituents of CSF from patients with bacterial meningitis differed quantitatively and qualitatively from those of CSF from uninfected patients or patients with nonbacterial infections. CSF from seven of eight patients with bacterial meningitis contained citramalic acid, a compound not previously identified in either normal or infected CSF. The implications of these findings are discussed.
Details
- Title: Subtitle
- Citramalic acid in cerebrospinal fluid of patients with bacterial meningitis
- Creators
- S PerlmanS A Carr
- Resource Type
- Journal article
- Publication Details
- Clinical chemistry, Vol.30(7), pp.1209-1212
- DOI
- 10.1093/clinchem/30.7.1209
- PMID
- 6145530
- NLM abbreviation
- Clin Chem
- ISSN
- 0009-9147
- eISSN
- 1530-8561
- Publisher
- England
- Language
- English
- Date published
- 07/1984
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777350302771
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