Journal article
Citrus Consumption and Risk of Cutaneous Malignant Melanoma in the Women's Health Initiative
Nutrition and cancer, Vol.72(4), pp.568-575
2020
DOI: 10.1080/01635581.2019.1644353
PMCID: PMC6980945
PMID: 31335211
Abstract
Citrus products are rich sources of furocoumarins, a class of photoactive compounds. Certain furocoumarins combined with ultraviolet radiation can induce skin cancer. We examined the relationship between citrus consumption and cutaneous melanoma risk among 56,205 Caucasian postmenopausal women in the Women's Health Initiative. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma by citrus intake level. During a mean follow-up of 15.7 years, 956 incident melanoma cases were documented. In multivariable adjusted models, the HR (95% CI) for melanoma was 1.12 (0.91, 1.37) among the highest citrus consumers (1.5+ servings/day of fruit or juice) versus the lowest (<2 servings/week), 0.95 (0.76, 1.20) among the highest citrus fruit consumers (5+ servings/week) versus non-consumers, and was 1.13 (0.96, 1.32) for the highest citrus juice consumers (1+ servings/day) versus the lowest (<1 serving/week). In stratified analyses, an increased melanoma risk associated with citrus juice intake was observed among women who spent the most time outdoors in summer as adults; the HR for the highest versus lowest intake was 1.22 (1.02, 1.46) (
trend = 0.03). Further research is needed to explore the association of melanoma with citrus juices among women with high sun exposure.
Details
- Title: Subtitle
- Citrus Consumption and Risk of Cutaneous Malignant Melanoma in the Women's Health Initiative
- Creators
- Melissa M Melough - Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USAShaowei Wu - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaWen-Qing Li - Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USACharles Eaton - Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USAHongmei Nan - IU Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USALinda Snetselaar - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USARobert Wallace - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USAAbrar A Qureshi - Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USAOck K Chun - Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USAEunyoung Cho - Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
- Resource Type
- Journal article
- Publication Details
- Nutrition and cancer, Vol.72(4), pp.568-575
- DOI
- 10.1080/01635581.2019.1644353
- PMID
- 31335211
- PMCID
- PMC6980945
- NLM abbreviation
- Nutr Cancer
- ISSN
- 0163-5581
- eISSN
- 1532-7914
- Publisher
- United States
- Grant note
- R21 CA198216 / NCI NIH HHS
- Language
- English
- Date published
- 2020
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984066107902771
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