Journal article
Classical conditioning increases membrane-bound protein kinase C in rabbit cerebellum
Neuroreport, Vol.9(11), pp.2669-2673
08/03/1998
DOI: 10.1097/00001756-199808030-00045
PMID: 9721953
Abstract
WE examined membrane-bound protein kinase C (PKC) in the cerebellum of rabbits given paired presentations of a tone conditioned stimulus (CS) that co-terminated with a periocular electrical stimulation unconditioned stimulus (US) or unpaired presentations of the CS and US or restraint in the experimental context. PKC activation was measured by quantitative film autoradiography of [3H]phorbol 12,13-dibutyrate ([H]PBt2) binding in the molecular and granule cells layers of lobule HVI, anterior vermis and Crus I, and in the dentate/interpositus nuclei. There was a statistically significant increase in [H]PBt2 binding within the molecular layer of lobule HVI in rabbits given paired training relative to controls. The results indicate PKC activation in lobule HVI may be important in acquisition of conditioned eyeblink responses.
Details
- Title: Subtitle
- Classical conditioning increases membrane-bound protein kinase C in rabbit cerebellum
- Creators
- John Freeman - 1Behavioral Neuroscience Unit, Laboratory of Adaptive Systems, Building 36, Room B205, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 2Department of Psychology, The University of Iowa, Iowa City, IA 3Department of Experimental Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 4Krasnow Institute for Advanced Studies, George Mason University, Fairfax, VA, USAAndrew ScharenbergJames OldsBernard Schreurs
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.9(11), pp.2669-2673
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00001756-199808030-00045
- PMID
- 9721953
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Language
- English
- Date published
- 08/03/1998
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065753702771
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