Journal article
Classification of Types of Stuttering Symptoms Based on Brain Activity
PloS one, Vol.7(6), pp.e39747-e39747
06/25/2012
DOI: 10.1371/journal.pone.0039747
PMCID: PMC3382568
PMID: 22761887
Abstract
Among the non-fluencies seen in speech, some are more typical (MT) of stuttering speakers, whereas others are less typical (LT) and are common to both stuttering and fluent speakers. No neuroimaging work has evaluated the neural basis for grouping these symptom types. Another long-debated issue is which type (LT, MT) whole-word repetitions (WWR) should be placed in. In this study, a sentence completion task was performed by twenty stuttering patients who were scanned using an event-related design. This task elicited stuttering in these patients. Each stuttered trial from each patient was sorted into the MT or LT types with WWR put aside. Pattern classification was employed to train a patient-specific single trial model to automatically classify each trial as MT or LT using the corresponding fMRI data. This model was then validated by using test data that were independent of the training data. In a subsequent analysis, the classification model, just established, was used to determine which type the WWR should be placed in. The results showed that the LT and the MT could be separated with high accuracy based on their brain activity. The brain regions that made most contribution to the separation of the types were: the left inferior frontal cortex and bilateral precuneus, both of which showed higher activity in the MT than in the LT; and the left putamen and right cerebellum which showed the opposite activity pattern. The results also showed that the brain activity for WWR was more similar to that of the LT and fluent speech than to that of the MT. These findings provide a neurological basis for separating the MT and the LT types, and support the widely-used MT/LT symptom grouping scheme. In addition, WWR play a similar role as the LT, and thus should be placed in the LT type.
Details
- Title: Subtitle
- Classification of Types of Stuttering Symptoms Based on Brain Activity
- Creators
- Jing Jiang - Beijing Normal UniversityChunming Lu - Beijing Normal UniversityDanling Peng - Beijing Normal UniversityChaozhe Zhu - Beijing Normal UniversityPeter Howell - University College London
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.7(6), pp.e39747-e39747
- DOI
- 10.1371/journal.pone.0039747
- PMID
- 22761887
- PMCID
- PMC3382568
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library Science
- Number of pages
- 11
- Grant note
- State Key Laboratory of Cognitive Neuroscience and Learning 30900393 / National Natural Science Foundation of China (NSFC)
- Language
- English
- Date published
- 06/25/2012
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984360129002771
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