Clean Photothermal Heating and Controlled Release from Near-Infrared Dye Doped Nanoparticles without Oxygen Photosensitization

Samit Guha; Scott K Shaw; Graeme T Spence; Felicia M Roland; Bradley D Smith

doi:10.1021/acs.langmuir.5b01878

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Clean Photothermal Heating and Controlled Release from Near-Infrared Dye Doped Nanoparticles without Oxygen Photosensitization

Journal article

Peer reviewed

Clean Photothermal Heating and Controlled Release from Near-Infrared Dye Doped Nanoparticles without Oxygen Photosensitization

Samit Guha, Scott K Shaw, Graeme T Spence, Felicia M Roland and Bradley D Smith

Langmuir, Vol.31(28), pp.7826-7834

07/21/2015

DOI: 10.1021/acs.langmuir.5b01878

PMCID: PMC4634570

PMID: 26149326

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https://www.ncbi.nlm.nih.gov/pmc/articles/4634570View

Open Access

Abstract

The photothermal heating and release properties of biocompatible organic nanoparticles, doped with a near-infrared croconaine (Croc) dye, were compared with analogous nanoparticles doped with the common near-infrared dyes ICG and IR780. Separate formulations of lipid-polymer hybrid nanoparticles and liposomes, each containing Croc dye, absorbed strongly at 808 nm and generated clean laser-induced heating (no production of (1)O2 and no photobleaching of the dye). In contrast, laser-induced heating of nanoparticles containing ICG or IR780 produced reactive (1)O2, leading to bleaching of the dye and also decomposition of coencapsulated payload such as the drug doxorubicin. Croc dye was especially useful as a photothermal agent for laser-controlled release of chemically sensitive payload from nanoparticles. Solution state experiments demonstrated repetitive fractional release of water-soluble fluorescent dye from the interior of thermosensitive liposomes. Additional experiments used a focused laser beam to control leakage from immobilized liposomes with very high spatial and temporal precision. The results indicate that fractional photothermal leakage from nanoparticles doped with Croc dye is a promising method for a range of controlled release applications.

Coloring Agents - chemistry

Delayed-Action Preparations

Doxorubicin - chemistry

Hot Temperature

Infrared Rays

Lasers

Liposomes - chemistry

Models, Molecular

Molecular Conformation

Nanoparticles - chemistry

Oxidation-Reduction

Photochemical Processes

Details

Title: Subtitle: Clean Photothermal Heating and Controlled Release from Near-Infrared Dye Doped Nanoparticles without Oxygen Photosensitization
Creators: Samit Guha - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
Scott K Shaw - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
Graeme T Spence - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
Felicia M Roland - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
Bradley D Smith - Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
Resource Type: Journal article
Publication Details: Langmuir, Vol.31(28), pp.7826-7834
DOI: 10.1021/acs.langmuir.5b01878
PMID: 26149326
PMCID: PMC4634570
NLM abbreviation: Langmuir
ISSN: 0743-7463
eISSN: 1520-5827
Grant note: P30 CA006973 / NCI NIH HHS R01 GM059078 / NIGMS NIH HHS T32GM075762 / NIGMS NIH HHS R01GM059078 / NIGMS NIH HHS T32 GM075762 / NIGMS NIH HHS
Language: English
Date published: 07/21/2015
Academic Unit: Chemistry
Record Identifier: 9984216614702771

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