Journal article
Clearance of Polychlorinated Biphenyl Atropisomers is Enantioselective in Female C57Bl/6 Mice
Environmental science & technology, Vol.44(8), pp.2828-2835
04/15/2010
DOI: 10.1021/es901781p
PMCID: PMC2855138
PMID: 20384376
Abstract
Changes in the enantiomer composition of polychlorinated biphenyls (PCBs) can not only be used to investigate environmental and biological transport processes, but also has human health implications because of enantiospecific adverse health effects. To further understand differences in the disposition of PCB atropisomers
in vivo
, the present study investigates the toxicokinetics of PCB atropisomers in female C57Bl/6 mice after oral administration of a mixture of several PCBs, including racemic PCBs 95, 132, 136, 149, 174 and 176. On the Chirasil-Dex column, an enrichment of the second eluting atropisomers was generally observed, whereas only the first eluting atropisomers E1-PCB 95, (−)-PCB 132 and (−)-PCB 149 had half-lives that were distinctively longer compared to the second eluting atropisomers. The bioavailability normalized clearance of first eluting atropisomers in blood was faster compared to second eluting atropisomers. The opposite trend was observed for the accumulation factors in adipose tissue, which is consistent with the slower clearance of the first eluting atropisomer. The only exception was PCB 174, which showed no differences in the toxicokinetic parameters of both atropisomers. Together, the differences in the toxicokinetics of PCB atropisomers point towards enantioselective biotransformation processes as the origin of PCB’s enantiomeric enrichment in mammals and, possibly, humans.
Details
- Title: Subtitle
- Clearance of Polychlorinated Biphenyl Atropisomers is Enantioselective in Female C57Bl/6 Mice
- Creators
- Izabela Kania-Korwel - Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242Mohammed H.M.E El-Komy - Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242Peter Veng-Pedersen - Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242Hans-Joachim Lehmler - Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Environmental science & technology, Vol.44(8), pp.2828-2835
- DOI
- 10.1021/es901781p
- PMID
- 20384376
- PMCID
- PMC2855138
- NLM abbreviation
- Environ Sci Technol
- ISSN
- 0013-936X
- eISSN
- 1520-5851
- Language
- English
- Date published
- 04/15/2010
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Iowa Superfund Research Program
- Record Identifier
- 9984001082402771
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