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Cleft palate: players, pathways, and pursuits
Journal article   Open access   Peer reviewed

Cleft palate: players, pathways, and pursuits

Jeffrey C Murray and Brian C Schutte
The Journal of clinical investigation, Vol.113(12), pp.1676-1678
06/15/2004
DOI: 10.1172/JCI22154
PMID: 15199400
url
https://doi.org/10.1172/JCI22154View
Published (Version of record) Open Access

Abstract

Cleft lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models. Mouse models in particular have made a substantial contribution to our understanding of the gene pathways involved in palate development and the nature of signaling molecules that act in a tissue-specific manner at critical stages of embryogenesis. Related work has provided further support for investigating the role of common environmental triggers as causal covariates.

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