Journal article
Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study
Kidney international reports, Vol.3(6), pp.1373-1384
11/01/2018
DOI: 10.1016/j.ekir.2018.07.021
PMCID: PMC6224619
PMID: 30450464
Abstract
Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.
Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. This is a descriptive analysis of clinical and treatment data collected at the time of enrollment.
Results: A total of 667 patients (506 IgAN, 161 IgAV) constitute the IgAN/IgAV cohort (382 adults, 285 children). At biopsy, those with IgAV were younger (13.0 years vs. 29.6 years, P < 0.001), more frequently white (89.7% vs. 78.9%, P= 0.003), had a higher estimated glomerular filtration rate (103.5 vs. 70.6 ml/min per 1.73 m(2), P < 0.001), and lower serum albumin (3.4 vs. 3.8 g/dl, P < 0.001) than those with IgAN. Adult and pediatric individuals with IgAV were more likely than those with IgAN to have been treated with immunosuppressive therapy at or prior to enrollment (79.5% vs. 54.0%, P < 0.001).
Conclusion: This report highlights clinical differences between IgAV and IgAN and between children and adults with these diagnoses. We identified differences in treatment with immunosuppressive therapies by disease type. This description of baseline characteristics will serve as a foundation for future CureGN studies.
Details
- Title: Subtitle
- Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study
- Creators
- David T. Selewski - University of MichiganJosephine M. Ambruzs - Arkana Labs, Little Rock, AR USAGerald B. Appel - Columbia UniversityAndrew S. Bomback - Columbia UniversityRaed Bou Matar - Cleveland ClinicYi Cai - Boston Children's HospitalDaniel C. Cattran - University Health NetworkAftab S. Chishti - University of KentuckyVivette D. D'Agati - Columbia University Irving Medical CenterCynthia J. D'Alessandri-Silva - Connecticut Children's Medical CenterRasheed A. Gbadegesin - Duke UniversityJonathan J. Hogan - Hospital of the University of PennsylvaniaSandra Iragorri - Oregon Health & Science UniversityJ. Charles Jennette - University of North Carolina at Chapel HillBruce A. Julian - University of Alabama at BirminghamMyda Khalid - Indiana UniversityRichard A. Lafayette - Stanford UniversityHelen Liapis - Arkana Labs, Little Rock, AR USAFrancesca Lugani - Istituto Giannina GasliniSarah A. Mansfield - Arbor Res Collaborat Hlth, Ann Arbor, MI USASherene Mason - Connecticut Children's Medical CenterPatrick H. Nachman - University of MinnesotaCynthia C. Nast - Cedars-Sinai Medical CenterCarla M. Nester - University of IowaDamien G. Noone - University Health NetworkJan Novak - University of Alabama at BirminghamMichelle M. O'Shaughnessy - Stanford UniversityHeather N. Reich - University Health NetworkMichelle N. Rheault - University of MinnesotaDana Rizk - University of Alabama at BirminghamManish K. Saha - University of North Carolina at Chapel HillNeil S. Sanghani - Vanderbilt University Medical CenterC. John Sperati - Johns Hopkins MedicineRajasree Sreedharan - Medical College of WisconsinTarak Srivastava - University of Missouri–Kansas CityAgnieszka Swiatecka-Urban - University of PittsburghKatherine Twombley - Medical University of South CarolinaTetyana L. Vasylyeva - Texas Tech University Health Sciences CenterDonald J. Weaver - Carolinas Medical CenterHong Yin - Emory UniversityJarcy Zee - Arbor Res Collaborat Hlth, Ann Arbor, MI USARonald J. Falk - University of North Carolina at Chapel HillAli G. Gharavi - Columbia UniversityBrenda W. Gillespie - University of MichiganDebbie S. Gipson - University of MichiganLarry A. Greenbaum - Emory UniversityLawrence B. Holzman - University of PennsylvaniaMatthias Kretzler - University of MichiganBruce M. Robinson - Arbor Res Collaborat Hlth, Ann Arbor, MI USAWilliam E. Smoyer - The Ohio State UniversityMichael Flessner - National Institutes of HealthLisa M. Guay-Woodford - Childrens Natl Hlth Syst, Ctr Translat Sci, Washington, DC USAKrzysztof Kiryluk - Columbia UniversityCureGN Consortium
- Resource Type
- Journal article
- Publication Details
- Kidney international reports, Vol.3(6), pp.1373-1384
- DOI
- 10.1016/j.ekir.2018.07.021
- PMID
- 30450464
- PMCID
- PMC6224619
- NLM abbreviation
- Kidney Int Rep
- ISSN
- 2468-0249
- eISSN
- 2468-0249
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- UM1DK100845; UM1DK100846; UM1DK100876; UM1DK100866; UM1DK100867 / NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) UM1DK100846 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) NephCure Kidney International
- Language
- English
- Date published
- 11/01/2018
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984354040102771
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