Clinical Effectiveness of Mupirocin for Preventing Staphylococcus aureus Infections in Nonsurgical Settings: A Meta-analysis

Rajeshwari Nair; Eli N Perencevich; Amy E Blevins; Michihiko Goto; Richard E Nelson; Marin L Schweizer

doi:10.1093/cid/civ901

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Clinical Effectiveness of Mupirocin for Preventing Staphylococcus aureus Infections in Nonsurgical Settings: A Meta-analysis

Journal article

Open access

Peer reviewed

Clinical Effectiveness of Mupirocin for Preventing Staphylococcus aureus Infections in Nonsurgical Settings: A Meta-analysis

Rajeshwari Nair, Eli N Perencevich, Amy E Blevins, Michihiko Goto, Richard E Nelson and Marin L Schweizer

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.62(5), pp.618-630

03/01/2016

DOI: 10.1093/cid/civ901

PMID: 26503378

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Abstract

A systematic literature review and meta-analysis was performed to identify effectiveness of mupirocin decolonization in prevention of Staphylococcus aureus infections, among nonsurgical settings. Of the 15 662 unique studies identified up to August 2015, 13 randomized controlled trials, 22 quasi-experimental studies, and 1 retrospective cohort study met the inclusion criteria. Studies were excluded if mupirocin was not used for decolonization, there was no control group, or the study was conducted in an outbreak setting. The crude risk ratios were pooled (cpRR) using a random-effects model. We observed substantial heterogeneity among included studies (I(2) = 80%). Mupirocin was observed to reduce the risk for S. aureus infections by 59% (cpRR, 0.41; 95% confidence interval [CI], .36-.48) and 40% (cpRR, 0.60; 95% CI, .46-.79) in both dialysis and nondialysis settings, respectively. Mupirocin decolonization was protective against S. aureus infections among both dialysis and adult intensive care patients. Future studies are needed in other settings such as long-term care and pediatrics.

Anti-Bacterial Agents - therapeutic use

Intensive Care Units

Humans

Staphylococcal Infections - prevention & control

Mupirocin - therapeutic use

Nose - microbiology

Renal Dialysis

Details

Title: Subtitle: Clinical Effectiveness of Mupirocin for Preventing Staphylococcus aureus Infections in Nonsurgical Settings: A Meta-analysis
Creators: Rajeshwari Nair - Department of Internal Medicine, University of Iowa Carver College of Medicine
Eli N Perencevich - Department of Internal Medicine, University of Iowa Carver College of Medicine
Amy E Blevins - Hardin Library for Health Sciences, University of Iowa, Iowa City
Michihiko Goto - Department of Internal Medicine, University of Iowa Carver College of Medicine
Richard E Nelson - IDEAS Center, Veterans Affairs Salt Lake City Health Care System, Utah
Marin L Schweizer - Department of Internal Medicine, University of Iowa Carver College of Medicine
Resource Type: Journal article
Publication Details: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.62(5), pp.618-630
DOI: 10.1093/cid/civ901
PMID: 26503378
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: United States
Grant note: name: Veterans Affairs Health Services and Research Career Development Award, award: CDA 11-215
Language: English
Date published: 03/01/2016
Academic Unit: Infectious Diseases; Epidemiology; Internal Medicine
Record Identifier: 9983779498102771

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