Journal article
Clinical Efficacy of Serum-Derived Bovine Immunoglobulin in Patients With Refractory Inflammatory Bowel Disease
The American journal of the medical sciences, Vol.356(6), pp.531-536
12/2018
DOI: 10.1016/j.amjms.2018.08.019
PMID: 30342719
Abstract
Inflammatory bowel disease (IBD) can have autoimmunity and/or intestinal barrier dysfunction as part of pathophysiology and may be refractory to all available treatment options. Serum-derived bovine immunoglobulin (SBI) binds microbial components with postulated downstream effects of normalized gut immune and barrier function, which may be useful for managing IBD. The purpose of our study was to evaluate the effectiveness of SBI in the management of refractory IBD, particularly symptoms of chronic diarrhea and loose stools.
We retrospectively analyzed charts for patients diagnosed with IBD (n = 40) who were refractory to standard treatment. Patients received oral SBI 5 g daily for a period of at least 6 weeks. Twelve patients with IBD fulfilled study inclusion criteria. Each patient graded the severity and frequency of gastrointestinal symptoms before starting SBI and at 6 weeks of treatment using a standardized patient assessment form. Means and standard deviations for all symptom scores at baseline and week 6 of treatment were analyzed.
Mean symptom scores decreased significantly for nausea (P = 0.02 for severity and P = 0.03 for mean symptom score) and diarrhea (P = 0.0006, P = 0.0001 and P = 0.0001 for severity, frequency and mean symptom score, respectively).
Therapy with SBI alleviated some refractory gastrointestinal symptoms in patients with IBD, including nausea and diarrhea. Increased duration, dosage and/or frequency of SBI might provide additional symptom improvement and could be tested through controlled clinical trials with larger sample sizes and longer follow-up.
Details
- Title: Subtitle
- Clinical Efficacy of Serum-Derived Bovine Immunoglobulin in Patients With Refractory Inflammatory Bowel Disease
- Creators
- Hammad Liaquat - Temple UniversityMunish Ashat - University of LouisvilleAbigail Stocker - University of LouisvilleLindsay McElmurray - University of Louisville PhysiciansKaren Beatty - University of LouisvilleThomas L. Abell - University of LouisvilleGerald Dryden - University of Louisville
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.356(6), pp.531-536
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.amjms.2018.08.019
- PMID
- 30342719
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 12/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359664202771
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