Journal article
Clinical Features and Racial/Ethnic Differences Among the 3020 Participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) Trial
Journal of stroke and cerebrovascular diseases, Vol.22(6), pp.764-774
08/2013
DOI: 10.1016/j.jstrokecerebrovasdis.2012.03.002
PMCID: PMC3970545
PMID: 22516427
Abstract
This study examined the baseline characteristics, racial/ethnic differences, and geographic differences among participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) study. The SPS3 trial enrolled patients who experienced a symptomatic small subcortical stroke (lacunar stroke) within the previous 6 months and an eligible lesion on detected on magnetic resonance imaging. The patients were randomized, in a factorial design, to antiplatelet therapy (aspirin 325 mg daily plus clopidogrel 75 mg daily vs aspirin 325 mg daily plus placebo) and to one of two levels of systolic blood pressure targets (“intensive” [<130 mmHg] or “usual” [130-149 mmHg]). A total of 3020 participants were recruited from 81 clinical sites in 8 countries. In this cohort, the mean age was 63 years, 63% were men, 75% had a history of hypertension, and 37% had diabetes. The racial distribution was 51% white, 30% Hispanic, and 16% black. Compared with white subjects, black subjects were younger (mean age, 58 years vs 64 years; P <.001) and had a higher prevalence of hypertension (87% vs 70%; P <.001). The prevalence of diabetes was higher in the Hispanic and black subjects compared with the white subjects (42% and 40% vs 32%; both P <.001). Tobacco smoking at the time of qualifying stroke was much more frequent in the Spanish participants than in subjects from North America and from Latin America (32%, 22%, and 9%, respectively; P <.001). Mean systolic blood pressure at study entry was 4 mmHg lower in the Spanish subjects compared with the North American subjects (P <.01). The SPS3 cohort is the largest magnetic resonance imaging–defined series of patients with S3. Among the racially/ethnically diverse SPS3 participants, important differences in patient features and vascular risk factors could influence prognosis for recurrent stroke and response to interventions.
Details
- Title: Subtitle
- Clinical Features and Racial/Ethnic Differences Among the 3020 Participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) Trial
- Creators
- Carole L White - School of Nursing, University of Texas Health Sciences Center at San Antonio, San Antonio, TexasJeff M Szychowski - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AlabamaAna Roldan - Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, CanadaMarie-France Benavente - Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, CanadaEdwin J Pretell - Hospital Alberto Sabogal, Lima, PeruOscar H Del Brutto - Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, EcuadorCarlos S Kase - Department of Neurology, Boston Medical Center, Boston, MassachusettsAntonio Arauz - Stroke Clinic, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco, Suárez, MexicoBrett C Meyer - Department of Neurosciences at UCSD, University of California, San Diego, CaliforniaIrene Meissner - Department of Neurology, Mayo Clinic, Rochester, MinnesotaBart M Demaerschalk - Division of Cerebrovascular Diseases, Department of Neurology, Mayo Clinic, Phoenix, ArizonaLeslie A McClure - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AlabamaChristopher S Coffey - Department of Biostatistics, University of Iowa, Iowa City, IowaLesly A Pearce - Biostatistician Consultant, Bel Air Court, Minot, North DakotaRobin Conwit - Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MarylandLisa H Irby - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AlabamaKalyani Peri - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AlabamaPablo E Pergola - Department of Neurology, University of Texas Health Sciences Center at San Antonio, San Antonio, TexasRobert G Hart - Population Health Research Institute, McMaster University, Hamilton, CanadaOscar R Benavente - Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, CanadaSPS3 Investigators
- Resource Type
- Journal article
- Publication Details
- Journal of stroke and cerebrovascular diseases, Vol.22(6), pp.764-774
- DOI
- 10.1016/j.jstrokecerebrovasdis.2012.03.002
- PMID
- 22516427
- PMCID
- PMC3970545
- NLM abbreviation
- J Stroke Cerebrovasc Dis
- ISSN
- 1052-3057
- eISSN
- 1532-8511
- Publisher
- Elsevier Inc
- Grant note
- 2U01 NS38529-04A1 / National Institute of Neurological Disorders and Stroke
- Language
- English
- Date published
- 08/2013
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997362602771
Metrics
23 Record Views