Journal article
Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
The journal of trauma, Vol.48(3), pp.558-561
03/2000
DOI: 10.1097/00005373-200003000-00036
PMID: 10744306
Abstract
BACKGROUND:The National Acute Spinal Cord Injury Studies have been a series of trials assessing the role of pharmacologic agents in the prevention of secondary neuronal damage after acute spinal cord injury.
METHODS:The trials were multicenter randomized, controlled studies.
RESULTS:Two trials have demonstrated the efficacy of high-dose methylprednisolone in improving neurologic and functional recovery and have shown a reassuring safety profile.
CONCLUSION:This study responds to a recent commentary on these trials and examines in particular the roles of clinical measurement, statistical analysis, and risk benefit in assembling evidence for or against innovative therapies.
Details
- Title: Subtitle
- Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
- Creators
- Michael Bracken - From the Departments of Epidemiology (M.B.B., M.J.S., V.P.), Biostatistics (T.R.H.), and Neurology (M.B.B.), Yale University School of Medicine, New Haven, Connecticut; and Departments of Emergency Medicine Neurosurgery, University of Maryland, Baltimore, Maryland (E.F.A.); Washington Hospital Center, Washington, DC (D.L.H.); University of Iowa Hospitals and Clinics, Iowa City, Iowa (P.W.H.); University of California at San Diego, San Diego, California (L.F.M.); Loyola University Medical Center, Maywood, Illinois (R.P.N.); Barrow Neurological Institute Phoenix, Arizona (V.K.H.S.); University of Washington-Harborview Medical Center, Seattle, Washington (R.W.); and New York University-Bellevue Medical Center, New York, New York (W.Y.)E. Francois AldrichDaniel HerrPatrick HitchonTheodore HolfordLawrence MarshallRuss NockelsValentine PascaleMary Jo ShepardVolker SonntagH. Richard WinnWise Young
- Resource Type
- Journal article
- Publication Details
- The journal of trauma, Vol.48(3), pp.558-561
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00005373-200003000-00036
- PMID
- 10744306
- ISSN
- 0022-5282
- eISSN
- 1529-8809
- Language
- English
- Date published
- 03/2000
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery
- Record Identifier
- 9984040352902771
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