Journal article
Clinical Nomogram Using Novel Computed Tomography-Based Radiomics Predicts Survival in Patients With Non-Small-Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy
JCO clinical cancer informatics, Vol.7(7), p.e2200173
06/01/2023
DOI: 10.1200/CCI.22.00173
PMCID: PMC10530405
PMID: 37369090
Abstract
Improved survival prediction and risk stratification in non-small-cell lung cancer (NSCLC) would lead to better prognosis counseling, adjuvant therapy selection, and clinical trial design. We propose the persistent homology (PHOM) score, the radiomic quantification of solid tumor topology, as a solution.
Patients diagnosed with stage I or II NSCLC primarily treated with stereotactic body radiation therapy (SBRT) were selected (N = 554). The PHOM score was calculated for each patient's pretreatment computed tomography scan (October 2008-November 2019). PHOM score, age, sex, stage, Karnofsky Performance Status, Charlson Comorbidity Index, and post-SBRT chemotherapy were predictors in the Cox proportional hazards models for OS and cancer-specific survival. Patients were split into high- and low-PHOM score groups and compared using Kaplan-Meier curves for overall survival (OS) and cumulative incidence curves for cause-specific death. Finally, we generated a validated nomogram to predict OS, which is publicly available at Eashwarsoma.Shinyapps.
PHOM score was a significant predictor for OS (hazard ratio [HR], 1.17; 95% CI, 1.07 to 1.28) and was the only significant predictor for cancer-specific survival (1.31; 95% CI, 1.11 to 1.56) in the multivariable Cox model. The median survival for the high-PHOM group was 29.2 months (95% CI, 23.6 to 34.3), which was significantly worse compared with the low-PHOM group (45.4 months; 95% CI, 40.1 to 51.8;
001). The high-PHOM group had a significantly greater chance of cancer-specific death at post-treatment month 65 (0.244; 95% CI, 0.192 to 0.296) compared with the low-PHOM group (0.171; 95% CI, 0.123 to 0.218;
= .029).
The PHOM score is associated with cancer-specific survival and predictive of OS. Our developed nomogram can be used to inform clinical prognosis and assist in making post-SBRT treatment considerations.
Details
- Title: Subtitle
- Clinical Nomogram Using Novel Computed Tomography-Based Radiomics Predicts Survival in Patients With Non-Small-Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy
- Creators
- Eashwar Somasundaram - Case Western Reserve UniversityRaoul R Wadhwa - Cleveland Clinic Lerner College of MedicineAdam Litzler - University of Colorado BoulderRowan Barker-Clarke - Cleveland Clinic Lerner College of MedicinePeng Qi - Cleveland ClinicGregory Videtic - Cleveland ClinicKevin Stephans - Cleveland ClinicNathan A Pennell - Cleveland ClinicDaniel Raymond - Cleveland ClinicKailin Yang - Cleveland ClinicMichael W Kattan - Cleveland Clinic Lerner College of MedicineJacob G Scott - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- JCO clinical cancer informatics, Vol.7(7), p.e2200173
- Publisher
- American Society of Clinical Oncology (ASCO)
- DOI
- 10.1200/CCI.22.00173
- PMID
- 37369090
- PMCID
- PMC10530405
- ISSN
- 2473-4276
- eISSN
- 2473-4276
- Grant note
- R37 CA244613 / NCI NIH HHS T32 CA094186 / NCI NIH HHS U54 CA274513 / NCI NIH HHS
- Language
- English
- Date published
- 06/01/2023
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696707802771
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