Journal article
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update
Clinical pharmacology and therapeutics, Vol.103(2), pp.210-216
02/2018
DOI: 10.1002/cpt.911
PMCID: PMC5760397
PMID: 29152729
Abstract
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5-fluorouracil and capecitabine). Detailed guidelines for the use of fluoropyrimidines, their clinical pharmacology, as well as analyses of cost-effectiveness are beyond the scope of this document. The Clinical Pharmacogenetics Implementation Consortium (CPIC (R)) guidelines consider the situation of patients for which genotype data are already available (updates available at https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/).
Details
- Title: Subtitle
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update
- Creators
- Ursula Amstutz - University Hospital of BernLinda M. Henricks - Oncode InstituteSteven M. Offer - Mayo ClinicJulia Barbarino - Stanford UniversityJan H. M. Schellens - Oncode InstituteJesse J. Swen - Leiden University Medical CenterTeri E. Klein - Stanford UniversityHoward L. McLeod - Moffitt Cancer CenterKelly E. Caudle - St. Jude Children's Research HospitalRobert B. Diasio - Mayo ClinicMatthias Schwab - Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.103(2), pp.210-216
- Publisher
- Wiley
- DOI
- 10.1002/cpt.911
- PMID
- 29152729
- PMCID
- PMC5760397
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 7
- Grant note
- Robert Bosch Foundation, Stuttgart, Germany National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R24GM61374 / PharmGKB R24GM115264 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 02/2018
- Academic Unit
- Pathology
- Record Identifier
- 9984618508902771
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