Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

David A. Talan; Fredrick M. Abrahamian; Gregory J. Moran; Diane M. Citron; Jonah O. Tan; Ellie J. C. Goldstein; Emergency Medicine Human Bite Infection Study Group

doi:10.1086/379331

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Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

Journal article

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Peer reviewed

Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

David A. Talan, Fredrick M. Abrahamian, Gregory J. Moran, Diane M. Citron, Jonah O. Tan, Ellie J. C. Goldstein and Emergency Medicine Human Bite Infection Study Group

Clinical infectious diseases, Vol.37(11), pp.1481-1489

12/2003

DOI: 10.1086/379331

PMID: 14614671

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Abstract

Previous studies of infected human bites have been limited by small numbers of patients and suboptimal microbiologic methodology. We conducted a multicenter prospective study of 50 patients with infected human bites. Seventy percent of the patients and assailants were young adult men. Fifty-six percent of injuries were clenched-fist injuries and 44% were occlusional bites. Most injuries were to the hands. Fifty-four percent of patients were hospitalized. The median number of isolates per wound culture was 4 (3 aerobes and 1 anaerobe); aerobes and anaerobes were isolated from 54% of wounds, aerobes alone were isolated from 44%, and anaerobes alone were isolated from 2%. Isolates included Streptococcus anginosus (52%), Staphylococcus aureus (30%), Eikenella corrodens (30%), Fusobacterium nucleatum (32%), and Prevotella melaninogenica (22%). Candida species were found in 8%. Fusobacterium, Peptostreptococcus, and Candida species were isolated more frequently from occlusional bites than from clenched-fist injuries. Many strains of Prevotella and S. aureus were β-lactamase producers. Amoxicillin—clavulanic acid and moxifloxacin demonstrated excellent in vitro activity against common isolates.

Details

Title: Subtitle: Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments
Creators: David A. Talan - 2UCLA School of Medicine, Los Angeles
Fredrick M. Abrahamian - 2UCLA School of Medicine, Los Angeles
Gregory J. Moran - 2UCLA School of Medicine, Los Angeles
Diane M. Citron - 3R. M. Alden Research Laboratory, Santa Monica, California
Jonah O. Tan - University of California, Los Angeles
Ellie J. C. Goldstein - 2UCLA School of Medicine, Los Angeles
Emergency Medicine Human Bite Infection Study Group
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.37(11), pp.1481-1489
DOI: 10.1086/379331
PMID: 14614671
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: The University of Chicago Press
Language: English
Date published: 12/2003
Academic Unit: Emergency Medicine; Internal Medicine
Record Identifier: 9984296984102771

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