Journal article
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves
Journal of clinical medicine, Vol.12(7), p.2568
03/29/2023
DOI: 10.3390/jcm12072568
PMID: 37048652
Abstract
Since COVID-19 was declared a pandemic, Brazil has become one of the countries most affected by this disease. A year into the pandemic, a second wave of COVID-19 emerged, with a rapid spread of a new SARS-CoV-2 lineage of concern. Several vaccines have been granted emergency-use authorization, leading to a decrease in mortality and severe cases in many countries. However, the emergence of SARS-CoV-2 variants raises the alert for potential new waves of transmission and an increase in pathogenicity. We compared the demographic and clinical data of critically ill patients infected with COVID-19 hospitalized in Rio de Janeiro during the first and second waves between July 2020 and October 2021. In total, 106 participants were included in this study; among them, 88% had at least one comorbidity, and 37% developed severe disease. Disease severity was associated with older age, pre-existing neurological comorbidities, higher viral load, and dyspnea. Laboratory biomarkers related to white blood cells, coagulation, cellular injury, inflammation, renal, and liver injuries were significantly associated with severe COVID-19. During the second wave of the pandemic, the necessity of invasive respiratory support was higher, and more individuals with COVID-19 developed acute hepatitis, suggesting that the progression of the second wave resulted in an increase in severe cases. These results can contribute to understanding the behavior of the COVID-19 pandemic in Brazil and may be helpful in predicting disease severity, which is a pivotal for guiding clinical care, improving patient outcomes, and defining public policies.
Details
- Title: Subtitle
- Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves
- Creators
- Luciane Almeida Amado - Oswaldo Cruz Inst Fiocruz, Lab Technol Dev Virol, BR-21040900 Rio De Janeiro, BrazilWagner Luis da Costa Nunes Pimentel Coelho - Oswaldo Cruz Inst Fiocruz, Lab Technol Dev Virol, BR-21040900 Rio De Janeiro, BrazilArthur Daniel Rocha Alves - Fundação Oswaldo CruzVanessa Cristine de Souza Carneiro - Oswaldo Cruz Inst Fiocruz, Lab Technol Dev Virol, BR-21040900 Rio De Janeiro, BrazilOtacilio da Cruz Moreira - Oswaldo Cruz Inst Fiocruz, Lab Mol Virol, BR-21040900 Rio De Janeiro, BrazilVanessa Salete de Paula - Fundação Oswaldo CruzAndreza Salvio Lemos - Fed Univ State Rio De Janeiro UNIRIO, Biomed Inst, Lab Translac Neurosci, BR-22290240 Rio De Janeiro, BrazilLarissa Araujo Duarte - Universidade Federal do Rio de JaneiroElisa Gouvea Gutman - Universidade Federal do Rio de JaneiroFabricia Lima Fontes-Dantas - Universidade do Estado do Rio de JaneiroJoao Paulo Da Costa Goncalves - Fed Univ State Rio De Janeiro UNIRIO, Biomed Inst, Lab Translac Neurosci, BR-22290240 Rio De Janeiro, BrazilCarlos Henrique Ferreira Ramos - Universidade Federal do Rio de JaneiroCarlos Henrique Ferreira Ramos Filho - Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Unit Intens Treatment, BR-21941901 Rio De Janeiro, BrazilMarta Guimaraes Cavalcanti - Universidade Federal do Rio de JaneiroMarisa Pimentel Amaro - Universidade Federal do Rio de JaneiroRafael Lopes Kader - Universidade Federal do Rio de JaneiroRoberto de Andrade Medronho - Univ Fed Rio de Janeiro, Sch Med, BR-21941901 Rio De Janeiro, BrazilDmitry Jose de Santana Sarmento - State Univ Paraiba, Sch Dent, Dept Oral Diag, BR-58429500 Araruna, BrazilSoniza Vieira Alves-Leon - Universidade Federal do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Journal of clinical medicine, Vol.12(7), p.2568
- DOI
- 10.3390/jcm12072568
- PMID
- 37048652
- NLM abbreviation
- J Clin Med
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Publisher
- Mdpi
- Number of pages
- 19
- Grant note
- E-26/201.406/2021; E-26/210.254/2020; E-26/210.657/2021; E-26/210.273/2018; E-26/201.040/2021; E-26/202.021/2020; E-26/210.817/2021; E-26/210.166/2020; E-26/201.243/2021; 403008/2021-2 / FAPERJ; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) MS/Programa Inova FIOCRUZ-Edital Geracao de Conhecimento-Enfrentamento da Pandemia e Pos-pandemia COVID-19: Encomendas Estrategicas Coordination for the Improvement of Higher Education Personnel-CAPES; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Edital Prociencia UERJ L.AAL E-26/210.192/2020 / CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
- Language
- English
- Date published
- 03/29/2023
- Academic Unit
- Neurology
- Record Identifier
- 9985180935602771
Metrics
1 Record Views