Journal article
Clinical Relevance of Immunobiology in Umbilical Cord Blood Transplantation
Journal of clinical medicine, Vol.8(11), p.1968
11/14/2019
DOI: 10.3390/jcm8111968
PMCID: PMC6912281
PMID: 31739455
Abstract
Umbilical cord blood transplantation (UCBT) has been an important donor source for allogeneic hematopoietic stem cell transplantation, especially for patients who lack suitable matched donors. UCBT provides unique practical advantages, such as lower risks of graft-versus-host-disease (GVHD), permissive HLA mismatch, and ease of procurement. However, there are clinical challenges in UCBT, including high infection rates and treatment-related mortality in selected patient groups. These clinical advantages and challenges are tightly linked with cell-type specific immune reconstitution (IR). Here, we will review IR, focusing on T and NK cells, and the impact of IR on clinical outcomes. Better understanding of the immune biology in UCBT will allow us to further advance this field with improved clinical practice.
Details
- Title: Subtitle
- Clinical Relevance of Immunobiology in Umbilical Cord Blood Transplantation
- Creators
- Hyun Don Yun - Rush UniversityAnkur Varma - Rush UniversityMohammad J. Hussain - Rush UniversitySunita Nathan - Rush UniversityClaudio Brunstein - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Journal of clinical medicine, Vol.8(11), p.1968
- DOI
- 10.3390/jcm8111968
- PMID
- 31739455
- PMCID
- PMC6912281
- NLM abbreviation
- J Clin Med
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Publisher
- Mdpi
- Number of pages
- 16
- Grant note
- Rush University Medical Center University of Minnesota; University of Minnesota System
- Language
- English
- Date published
- 11/14/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985164328302771
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