Journal article
Clinical Significance of Postradiotherapy [18F]-Fluorodeoxyglucose Positron Emission Tomography Imaging in Management of Head-and-Neck Cancer—A Long-Term Outcome Report
International journal of radiation oncology, biology, physics, Vol.74(1), pp.9-14
2009
DOI: 10.1016/j.ijrobp.2008.07.019
PMID: 18930358
Abstract
To determine the accuracy and prognostic significance of post-treatment [
18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) in head-and-neck squamous cell carcinoma after radiotherapy (RT).
This was a retrospective study of 188 patients with head-and-neck squamous cell carcinoma who had undergone FDG-PET within 12 months after completing RT. All living patients had ≥1 year of follow-up after FDG-PET. All patients had undergone intensity-modulated RT, 128 with definitive and 60 with postoperative intensity-modulated RT.
For all patients, the median follow-up after RT completion was 32.6 months and after FDG-PET was 29.2 months. For the neck, 171 patients had negative FDG-PET findings. Of these results, two were falsely negative. Seventeen patients had positive FDG-PET findings, of which 12 were true-positive findings. The sensitivity, specificity, positive predictive value, and negative predictive value for FDG-PET in the assessment of the treatment response in the neck was 86%, 97%, 71%, and 99%, respectively. For the primary site, 151 patients had negative FDG-PET findings, of which two were falsely negative. Thirty-seven patients had positive FDG-PET findings, of which 12 were true-positive findings. The sensitivity, specificity, positive predictive value, and negative predictive value for FDG-PET in the assessment of the treatment response in the primary site was 86%, 86%, 32.4%, and 98.7%, respectively. Patients with positive post-RT PET findings had significantly worse 3-year overall survival and disease-free survival.
The results of our study have shown that the findings of post-RT FDG-PET have a high negative predictive value and are a significant prognostic factor. It can provide guidance for the management of head-and-neck cancer after definitive treatment.
Details
- Title: Subtitle
- Clinical Significance of Postradiotherapy [18F]-Fluorodeoxyglucose Positron Emission Tomography Imaging in Management of Head-and-Neck Cancer—A Long-Term Outcome Report
- Creators
- Min Yao - Department of Radiation Oncology, University Hospitals Case Medical Center, Cleveland, OHRussell B Smith - Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NEHenry T Hoffman - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IAGerry F Funk - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IAMinggen Lu - University of Nevada at Reno School of Public Health, Reno, NVYusuf Menda - Department of Radiology, University of Iowa, Iowa City, IAMichael M Graham - Department of Radiology, University of Iowa, Iowa City, IAJohn M Buatti - Department of Radiation Oncology, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.74(1), pp.9-14
- DOI
- 10.1016/j.ijrobp.2008.07.019
- PMID
- 18930358
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2009
- Academic Unit
- Radiology; Radiation Oncology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984006484602771
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