Journal article
Clinical Trials Targeting Aging and Age-Related Multimorbidity
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.72(3), pp.355-361
03/01/2017
DOI: 10.1093/gerona/glw220
PMCID: PMC5777384
PMID: 28364543
Abstract
There is growing interest in identifying interventions that may increase health span by targeting biological processes underlying aging. The design of efficient and rigorous clinical trials to assess these interventions requires careful consideration of eligibility criteria, outcomes, sample size, and monitoring plans.
Experienced geriatrics researchers and clinical trialists collaborated to provide advice on clinical trial design.
Outcomes based on the accumulation and incidence of age-related chronic diseases are attractive for clinical trials targeting aging. Accumulation and incidence rates of multimorbidity outcomes were developed by selecting at-risk subsets of individuals from three large cohort studies of older individuals. These provide representative benchmark data for decisions on eligibility, duration, and assessment protocols. Monitoring rules should be sensitive to targeting aging-related, rather than disease-specific, outcomes.
Clinical trials targeting aging are feasible, but require careful design consideration and monitoring rules.
Details
- Title: Subtitle
- Clinical Trials Targeting Aging and Age-Related Multimorbidity
- Creators
- Mark A Espeland - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaEileen M Crimmins - Davis School of Gerontology, University of Southern California, Los AngelesBrandon R Grossardt - Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MinnesotaJill P Crandall - Department of Medicine, Albert Einstein College of Medicine, Bronx, New YorkJonathan A L Gelfond - Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San AntonioTamara B Harris - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MarylandStephen B Kritchevsky - Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North CarolinaJoAnn E Manson - Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsJennifer G Robinson - University of Iowa Carver College of MedicineWalter A Rocca - Department of Neurology, Mayo Clinic, Rochester, MinnesotaMarinella Temprosa - The Biostatistics Center, The George Washington University, Rockville, MarylandFridtjof Thomas - Department of Preventive Medicine, University of Tennessee Health Science Center, MemphisRobert Wallace - University of Iowa Carver College of MedicineNir Barzilai - The Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New YorkMultimorbidity Clinical Trials Consortium
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.72(3), pp.355-361
- DOI
- 10.1093/gerona/glw220
- PMID
- 28364543
- PMCID
- PMC5777384
- NLM abbreviation
- J Gerontol A Biol Sci Med Sci
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Publisher
- United States
- Grant note
- P30 AG013319 / NIA NIH HHS U01 AG009740 / NIA NIH HHS R01 AG034676 / NIA NIH HHS R01 AR030582 / NIAMS NIH HHS P30 AG021332 / NIA NIH HHS P30 AG038072 / NIA NIH HHS R01 GM070335 / NIGMS NIH HHS R01 AG052425 / NIA NIH HHS P30 AG044271 / NIA NIH HHS
- Language
- English
- Date published
- 03/01/2017
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983996197402771
Metrics
26 Record Views