Clinical Utility and Safety of Fecal Microbiota Transplantation to Children with Refractory Ulcerative Colitis

Toshifumi Yodoshi; Itaru Iwama; Kaoru Kikuchi; Masato Katsuren; Ruriko Izumikawa; Yukiko Gibu

doi:10.11244/jspen.33.881

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$Clinical Utility and Safety of Fecal Microbiota Transplantation to Children with Refractory Ulcerative Colitis$

Journal article

Peer reviewed

Clinical Utility and Safety of Fecal Microbiota Transplantation to Children with Refractory Ulcerative Colitis

Toshifumi Yodoshi, Itaru Iwama, Kaoru Kikuchi, Masato Katsuren, Ruriko Izumikawa and Yukiko Gibu

Journal of Japanese Society for Parenteral and Enteral Nutrition, Vol.33(3), pp.881-887

2018

DOI: 10.11244/jspen.33.881

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Abstract

Objective: The purpose of this study was to clarify the clinical utility of fecal microbiota transplantation (FMT) to children with severe refractory UC.Patients and methods: A single-center, descriptive study was undertaken between August 2015 and July 2017 at Okinawa Chubu Hospital. FMT was performed in four patients with refractory UC (2–14 years old) who had not responded to infliximab, cyclosporin, tacrolimus, or leukocytapheresis. Three of the patients were administered the FMT via elemental diet tubes, whereas the fourth received the FMT via colonoscopy. The following variables were evaluated using the patients' medical records: age, medication history, route of FMT administration, clinical course, PUCAI (Pediatric Ulcerative Colitis Activity Index) scores and FMT's complications.Results: One patient experienced clinical remission for 24 months, and two patients experienced clinical remission for a few weeks. No severe complications occurred.Conclusion: FMT appears to be safe for children with severe refractory UC. FMT may have utility as a temporizing induction therapy for severe refractory UC prior to the ultimately necessary step of surgery.

fecal microbiota

fecal microbiota transplantation

pediatric ulcerative colitis

Details

Title: Subtitle: Clinical Utility and Safety of Fecal Microbiota Transplantation to Children with Refractory Ulcerative Colitis
Creators: Toshifumi Yodoshi - Division of Clinical Epidemiology, Jikei University Graduate School of Medicine
Itaru Iwama - Saitama Children's Medical Center
Kaoru Kikuchi - Okinawa Prefectural Yaeyama Hospital
Masato Katsuren - Department of Pharmacy, Okinawa Chubu Hospital
Ruriko Izumikawa - Department of Nutrition, Okinawa Chubu Hospital
Yukiko Gibu - Department of Nutrition, Okinawa Chubu Hospital
Resource Type: Journal article
Publication Details: Journal of Japanese Society for Parenteral and Enteral Nutrition, Vol.33(3), pp.881-887
DOI: 10.11244/jspen.33.881
ISSN: 2189-0161
eISSN: 2189-017X
Publisher: Japanese Society for Parenteral and Enteral Nutrition
Language: Japanese
Date published: 2018
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9985217140302771

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