Clinical Utility of Contemporary Digital Infusion Submandibular Sialography

Evgeniya Molotkova; Piper Wenzel; Jeff Sylte; Sean Fain; Joan Maley; Ryan Thorpe; Henry Hoffman

doi:10.1002/lio2.70248

Back

Clinical Utility of Contemporary Digital Infusion Submandibular Sialography

Journal article

Open access

Peer reviewed

Clinical Utility of Contemporary Digital Infusion Submandibular Sialography

Evgeniya Molotkova, Piper Wenzel, Jeff Sylte, Sean Fain, Joan Maley, Ryan Thorpe and Henry Hoffman

Laryngoscope investigative otolaryngology, Vol.10(4), e70248

08/21/2025

DOI: 10.1002/lio2.70248

PMCID: PMC12369398

PMID: 40852583

Appears in UI Libraries Support Open Access

Files and links (1)

url

https://doi.org/10.1002/lio2.70248View

Published (Version of record) Open Access

Abstract

Objectives Contemporary sialography couples mechanical ductal dilation with hydrodilation and utilizes iodinated contrast with antimicrobial properties to generate diagnostic data. This procedure has been reported to have therapeutic value that has not been investigated in a large contemporary series. This study examines the therapeutic value of diagnostic digital infusion submandibular sialography. Methods Retrospective chart review of a consecutive series of submandibular sialograms from April 2008 to November 2024, focusing on symptomatic response to sialography. Results Review identified 135 submandibular sialograms with follow-up addressing post-study symptom assessment available in 67. Indications for sialography in this group included pain (6/67), swelling (23/67), or both (38/67). Symptomatic improvement following sialography was reported in 67% of cases (45/67). Those reporting initial complete relief of symptoms rarely (15%) required additional treatment during the follow-up period (p = 0.019). The radiographic diagnosis of a distal stricture was associated with a higher rate of symptom improvement (78%) when compared to those without a distal stricture (57%) (p = 0.049). Among patients in this cohort, the median effective radiation dose (1.94 mSv) for the CT imaging preceding sialography (N = 39) was significantly greater than that calculated radiation dose (0.14 mSv) for one-gland sialography (N = 42) (p < 0.001). Conclusion Diagnostic submandibular sialography is often therapeutic and is performed with limited radiation exposure. Prospective study is ongoing to provide more detailed evaluation of the therapeutic impact of this procedure.

Original Research

UIOWA OA Agreement

Details

Title: Subtitle: Clinical Utility of Contemporary Digital Infusion Submandibular Sialography
Creators: Evgeniya Molotkova - University of Iowa
Piper Wenzel - University of Iowa
Jeff Sylte - University of Iowa
Sean Fain - University of Iowa, Radiology
Joan Maley - University of Iowa
Ryan Thorpe - University of Iowa
Henry Hoffman - University of Iowa
Resource Type: Journal article
Publication Details: Laryngoscope investigative otolaryngology, Vol.10(4), e70248
DOI: 10.1002/lio2.70248
PMID: 40852583
PMCID: PMC12369398
NLM abbreviation: Laryngoscope Investig Otolaryngol
ISSN: 2378-8038
eISSN: 2378-8038
Publisher: Wiley
Language: English
Date published: 08/21/2025
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; The University of Iowa Institute for Vision Research; Radiation Oncology; Otolaryngology; Health, Sport, and Human Physiology
Record Identifier: 9984948008102771

Metrics

3 Record Views