Journal article
Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study
Journal of pediatric gastroenterology and nutrition, Vol.71(1), pp.112-118
07/2020
DOI: 10.1097/MPG.0000000000002661
PMCID: PMC7305964
PMID: 32079978
Abstract
The aim of the study was to determine whether clinical characteristics and management of pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) differ across INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In Search for a cuRE) sites.
Data were collected from INSPPIRE and analyzed per US regions and "non-US" sites. Between-group differences were compared by Pearson chi-square test. Differences in disease burden were compared by Kruskal-Wallis test.
Out of the 479 subjects, 121 (25%) were enrolled in West, 151 (32%) Midwest, 45 Northeast (9%), 78 (16%) South, and 84 (18%) at non-US sites. Hispanic ethnicity was more common in South (P < 0.0001); white race in Northeast (P = 0.009). CP was less common and time from diagnosis of first acute pancreatitis to CP was longer in children at non-US sites (P = 0.0002 and P = 0.011, respectively). Genetic mutations were most common among all groups; PRSS1 variants predominated in Midwest (P = 0.002). Gallstones were more frequent in South (P = 0.002). Endoscopic retrograde cholangiopancreatography (ERCP) and computed tomography (CT) imaging were more commonly utilized in United States compared with non-United States (P < 0.0001), but there were no differences in the use of MRI/MRCP. Disease burden was highest in the West and Midwest, possibly as total pancreatectomy and islet autotransplantation (TPIAT) referral sites were located in these regions. All therapies were less commonly administered in non-US sites (P < 0.0001).
This is the first study to describe geographical variations in the INSPPIRE cohort, which possibly reflect variations in practice and referral patterns. The underlying reason behind the lower frequency of CP and fewer treatments in non-United States sites need to be further explored.
Details
- Title: Subtitle
- Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study
- Creators
- Chinenye R Dike - Department of Pediatrics, University of Nebraska Medical Center, Omaha, NEBridget Zimmerman - Department of Biostatistics, University of Iowa, Iowa City, IAYuhua Zheng - Children's Hospital of Los Angeles, Los Angeles, CAMichael Wilschanski - Hadassah Hebrew University Hospital, Jerusalem, IsraelSteven L Werlin - Medical College of Wisconsin, Milwaukee, WIDavid Troendle - University of Texas Southwestern Medical School, Dallas, TXUzma Shah - Massachusetts General Hospital for Children, Harvard Medical School, Boston, MASarah Jane Schwarzenberg - University of Minnesota Masonic Children's Hospital, Minneapolis, MNJohn Pohl - University of Utah, Salt Lake City, UTEmily R Perito - University of California San Francisco, San Francisco, CAChee Y Ooi - School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick, Sydney, AustraliaJaimie D Nathan - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OHVeronique D Morinville - Montreal Children's Hospital, McGill University, Montreal, QC, CanadaBrian McFerron - Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INMaria Mascarenhas - Children's Hospital of Philadelphia, Philadelphia, PAAsim Maqbool - Children's Hospital of Philadelphia, Philadelphia, PAQuin Liu - Cedars-Sinai Medical Center, LATom K Lin - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OHSohail Z Husain - Stanford University, Palo Alto, CAMelvin B Heyman - University of California San Francisco, San Francisco, CATanja Gonska - Hospital for Sick Children, Toronto, ONMatthew J Giefer - Seattle Children's Hospital, Seattle, WACheryl E Gariepy - Nationwide Children's Hospital, Columbus, OHDouglas S Fishman - Baylor College of Medicine, Houston, TXMelena Bellin - University of Minnesota Masonic Children's Hospital, Minneapolis, MNBradley Barth - University of Texas Southwestern Medical School, Dallas, TXMaisam Abu-El-Haija - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OHMark E Lowe - Washington University School of Medicine, St. Louis, MOAliye Uc - Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.71(1), pp.112-118
- DOI
- 10.1097/MPG.0000000000002661
- PMID
- 32079978
- PMCID
- PMC7305964
- NLM abbreviation
- J Pediatr Gastroenterol Nutr
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Grant note
- R01 DK118752 / NIDDK NIH HHS UL1 TR000442 / NCATS NIH HHS U01 DK108334 / NIDDK NIH HHS R21 DK096327 / NIDDK NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 07/2020
- Academic Unit
- Stead Family Department of Pediatrics; Biostatistics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984214813502771
Metrics
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