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Clinical and biologic antecedents of the amenorrhea/hyperprolactinemia syndrome: a case-control study
Journal article   Open access   Peer reviewed

Clinical and biologic antecedents of the amenorrhea/hyperprolactinemia syndrome: a case-control study

Robert B. Wallace, Barry M. Sherman and Judy A. Bean
Fertility and sterility, Vol.43(5), pp.726-732
05/1985
DOI: 10.1016/S0015-0282(16)48555-9
PMID: 3996617
url
https://doi.org/10.1016/s0015-0282(16)48555-9View
Published (Version of record) Open Access

Abstract

Clinical, reproductive, and biologic antecedents of women with the amenorrhea/hyperprolactinemia (A/H) syndrome, most with pituitary prolactinomas, and matched healthy subjects were examined in a case-control study. Women with A/H had more frequent irregularity in early menstrual cycle patterns and excess facial hair, had less frequent catamenial symptoms, and were heavier at the time of study when compared with control subjects. The patients reported a more frequent history of thyroid disease and chest trauma. There were no significant differences between the patients and control subjects with respect to prior use of oral contraceptives, estrogens, psychotropic drugs, alcohol, or other substances known to alter serum prolactin levels, nor were there significant differences in the family history of gynecologic conditions or malignancies or the syndromes of multiple endocrine neoplasia. The implications of these findings are discussed.

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