Journal article
Clinical and environmental influences on metabolic biomarkers collected for newborn screening
Clinical biochemistry, Vol.46(1-2), pp.133-138
01/2013
DOI: 10.1016/j.clinbiochem.2012.09.013
PMCID: PMC3534803
PMID: 23010448
Abstract
Identifying common clinical and environmental factors that influence newborn metabolic biomarkers will improve the utilization of metabolite panels for clinical diagnostic medicine.
Environmental effects including gender, season of birth, gestational age, birth weight, feeding method and age at time of collection were evaluated for over 50 metabolites collected by the Iowa Neonatal Metabolic Screening Program on 221,788 newborns over a six year period.
We replicated well known observations that low birth weight and preterm infants have higher essential amino acids and lower medium and long chain acylcarnitine levels than their term counterparts. Smaller, but still significant, differences were observed for gender and timing of sample collection, specifically the season in which the infant was born. Most intriguing were our findings of higher thyroid stimulating hormone in the winter months (P<1×10−40) which correlated with an increased false positive rate of congenital hypothyroidism in the winter (0.9%) compared to summer (0.6%). Previous studies, conducted globally, have identified an increased prevalence of suspected and confirmed cases of congenital hypothyroidism in the winter months. We found that the percentage of unresolved suspected cases were slightly higher in the winter (0.3% vs. 0.2%).
We identified differences in metabolites by gestational age, birth weight, gender and season. Some are widely reported such as gestational age and birth weight, while others such as the effect of seasonality are not as well studied.
► We examine the demographic and environmental impact on analytes obtained through routine newborn screening. ► Increasing essential amino acid levels are associated with decreasing birth weight and gestational age. ► Levels of thyroid stimulating hormone and immunoreactive trypsinogen are higher in the winter months of collection.
Details
- Title: Subtitle
- Clinical and environmental influences on metabolic biomarkers collected for newborn screening
- Creators
- Kelli K Ryckman - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USAStanton L Berberich - State Hygienic Laboratory, University of Iowa, Iowa City, IA, USAOleg A Shchelochkov - Division of Genetics, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USADaniel E Cook - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USAJeffrey C Murray - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Clinical biochemistry, Vol.46(1-2), pp.133-138
- DOI
- 10.1016/j.clinbiochem.2012.09.013
- PMID
- 23010448
- PMCID
- PMC3534803
- NLM abbreviation
- Clin Biochem
- ISSN
- 0009-9120
- eISSN
- 1873-2933
- Publisher
- Elsevier Inc
- Grant note
- R01 HD-52953; R01 HD-57192 / National Institute of Health 5T32 HL 007638‐24 / NIH/NRSA T-32 training grant K99 HD-065786 / Eunice Kennedy Shriver National Institute of Child Health and Human Development March of Dimes 1-FY05-126 6-FY08-260 2224 / Children's Miracle Network
- Language
- English
- Date published
- 01/2013
- Academic Unit
- Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9983995174702771
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