Journal article
Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease
Current opinion in nephrology and hypertension, Vol.22(4), pp.452-458
07/2013
DOI: 10.1097/MNH.0b013e328362483a
PMID: 23680649
Abstract
The concepts of steady state, external balance, total body status and internal distribution are not always appreciated or even considered in clinical practice. The current tests available for clinical assessment of phosphorus physiology and pathophysiology are valid in some aspects, but also have many limitations. The purpose of this review is to clarify the above concepts and discuss the utility of the currently available tests to assess phosphorus disorders.
Both epidemiologic and preclinical data have shown that disturbances in mineral metabolism contribute significantly to the morbidity and mortality in chronic kidney disease. There are also emerging data supporting the notion that phosphotoxicity may exist even in individuals with normal renal function. In chronic kidney disease (CKD), hyperphosphatemia is a relative late event and is a suboptimal indicator of phosphorus balance and status. The judicious use of plasma and urine chemistry and hormonal biomarkers such as fibroblast growth factor 23 should be considered.
There is a dire need to increase awareness of what physiologic parameters should be monitored in terms of phosphorus pathophysiology. Although the current available tests in the clinical armamentarium are not ideal, understanding their implications and limitations will improve patient care and motivate practitioners and investigators to develop better tests.
Details
- Title: Subtitle
- Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease
- Creators
- Chou-Long Huang - Department of Internal Medicine, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas 75390-8856, USA. chou-long.huang@utsouthwestern.eduOrson W Moe
- Resource Type
- Journal article
- Publication Details
- Current opinion in nephrology and hypertension, Vol.22(4), pp.452-458
- DOI
- 10.1097/MNH.0b013e328362483a
- PMID
- 23680649
- ISSN
- 1062-4821
- eISSN
- 1473-6543
- Grant note
- DK59530 / NIDDK NIH HHS DK79328 / NIDDK NIH HHS P30 DK079328 / NIDDK NIH HHS DK92461 / NIDDK NIH HHS DK91392 / NIDDK NIH HHS DK85726 / NIDDK NIH HHS
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094644902771
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