Journal article
Clinical characteristics and outcome correlates of Chinese patients with takotsubo syndrome: Results from the first Chinese takotsubo syndrome registry
International journal of cardiology, Vol.387, 131129
09/2023
DOI: 10.1016/j.ijcard.2023.131129
PMID: 37355242
Abstract
To investigate clinical features and outcomes of Chinese patients with Takotsubo syndrome (TTS).
We established the first Chinese Registry of Takotsubo Syndrome (ChiTTS Registry) and analyzed demographic, clinical, therapeutical, and outcome data to characterize clinical and outcome features of Chinese TTS patients.
In 112 enrolled patients in the ChiTTS registry from 02/01/2016 to 12/28/2021, the mean age was 59.4 ± 18.7 years old, and 27.7% were men. A total of 41.1% patients experienced respiratory and circulatory complications during hospitalization, and 17.3% patients developed cardiogenic shock. Physical triggers, dyspnea, tachycardia, and younger age (< 70 years old) predicted in-hospital complications. The MACCE rate during follow up was 13.9% per patient per year and the rate of all-cause death was 12.8% per patient per year. TTS patients with in-hospital complications developed more long-term MACCE (24.6% vs. 6.6% per patient-year, P < 0.001) and higher all-cause mortality (21.9% vs. 6.6% per patient-year, P = 0.001) than those without. The Kaplan-Meier survival analysis showed that more MACCE occurred in TTS patients with tachycardia during 3-year follow-up (HR 4.18; 95% CI 1.80–9.74; log-rank test P < 0.001). Among all medications at discharge, only beta-blocker was associated with reduced long-term MACCE (HR: 0.35; 95% CI: 0.12–0.996; P = 0.049).
We investigated clinical and outcome features of patients in the first Chinese TTS Registry. Tachycardiac TTS patients developed more inpatient and long-term adverse cardiovascular events.
•The clinical characteristics of Chinese patients with Takotsubo syndrome (TTS) is largely unknown, which prevents from developing personalized treatment strategies.•Chinese TTS patients in ChiTTS Registry show different clinical features and outcomes when compared with European and American TTS patients.•Tachycardia in ChiTTS Registry patients is associated with worse long-term outcomes, and beta-blockers show the potential to improve long-term outcomes.
Details
- Title: Subtitle
- Clinical characteristics and outcome correlates of Chinese patients with takotsubo syndrome: Results from the first Chinese takotsubo syndrome registry
- Creators
- Tou Kun Chong - Kiang Wu HospitalJian Chen - Fifth Affiliated Hospital of Sun Yat-sen UniversityLingchun Lyu - Lishui UniversityYulin Wei - Sun Yat-sen Memorial HospitalYusheng Liu - Second Hospital of Shandong UniversityLiwen Wu - Guangzhou Medical UniversityYuan Tao - Sheng Jing HospitalLingzhi Jiang - Hangzhou Medical CollegeZhongxia Sun - Zhejiang UniversityDabin Li - Kiang Wu HospitalQianglin Guan - Fifth Affiliated Hospital of Sun Yat-sen UniversityFangyuan Cheng - Fifth Affiliated Hospital of Sun Yat-sen UniversityYongmin Ding - Sheng Jing HospitalPengfei Miao - Xian Central HospitalChenying Lu - Lishui UniversityJuan Lei - Sun Yat-sen Memorial HospitalTiemin Wei - Lishui UniversityTiangang Zhu - Thrombolysis in Myocardial Infarction Study GroupKan Liu - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology, Vol.387, 131129
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ijcard.2023.131129
- PMID
- 37355242
- ISSN
- 0167-5273
- eISSN
- 1874-1754
- Language
- English
- Electronic publication date
- 06/22/2023
- Date published
- 09/2023
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984438856802771
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