Journal article
Clinical course of postthrombotic syndrome in children with history of venous thromboembolism
Blood coagulation & fibrinolysis, Vol.23(1), pp.39-44
2012
DOI: 10.1097/MBC.0b013e32834bdb1c
PMID: 22089938
Abstract
Postthrombotic syndrome (PTS) is a chronic morbidity of venous thromboembolism (VTE) in children. Information about the evolution of PTS is lacking in children. Present study was aimed to evaluate the time-course of extremity PTS in children who were serially followed in a hematology clinic. This retrospective cohort study included 69 consecutive children with documented VTEs that presented with symptoms of extremity VTE: 67 extremity VTEs with or without extension to vena cava, 2 inferior vena cava VTEs. Severity of PTS was assessed using modified Villalta scale. Median age of the cohort was 12.6 years (interquartile range 1.6-15 years) while median follow-up was 28.7 months (interquartile range 13.3-33.4 months. PTS prevalence was 46.8% [95% confidence interval (CI) 37.9-57.7%]. Lower extremity VTE was associated with development of PTS compared to upper extremity VTE regardless of catheter use (P = 0.002). The time-course of PTS fluctuated in 11 of 33 children (33%; 95% CI 20-47%) at a median interval of 12 months from diagnosis of VTE (range 4-14 months): three progressed from mild/moderate to severe, one improved from moderate to mild, seven fluctuated between mild and moderate. Recurrence and incomplete resolution of VTE were associated with variability in PTS severity (P < 0.05). In summary, this study suggested that almost 50% of study cohort developed PTS, and the time-course of PTS was not static in one third of children. Future research should focus on identifying the predictors contributing to the worsening of PTS and developing risk-stratified treatment interventions so as to improve the outcome of children with VTE.
Details
- Title: Subtitle
- Clinical course of postthrombotic syndrome in children with history of venous thromboembolism
- Creators
- Susan CREARY - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesMark HEINY - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesJames CROOP - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesRobert FALLON - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesTerry VIK - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesMonica HULBERT - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesHolly KNODERER - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesManjusha KUMAR - Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, United StatesAnjali SHARATHKUMAR - Department of Pediatrics, Children's Memorial Hospital, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United States
- Resource Type
- Journal article
- Publication Details
- Blood coagulation & fibrinolysis, Vol.23(1), pp.39-44
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MBC.0b013e32834bdb1c
- PMID
- 22089938
- ISSN
- 0957-5235
- eISSN
- 1473-5733
- Language
- English
- Date published
- 2012
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093218602771
Metrics
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