Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case

Ajmain Chowdhury; Alex Belzer; Nahom Teferi; Hend Al-Kaylani; Juan Vivanco-Suarez; Assim Saad Eddin; Kathryn Eschbacher; Mohammed Milhem; Patrick Hitchon

doi:10.3171/CASE23338

Back

Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case

Journal article

Open access

Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case

Ajmain Chowdhury, Alex Belzer, Nahom Teferi, Hend Al-Kaylani, Juan Vivanco-Suarez, Assim Saad Eddin, Kathryn Eschbacher, Mohammed Milhem and Patrick Hitchon

Journal of Neurosurgery: Case Lessons, Vol.6(8), CASE23338

08/21/2023

DOI: 10.3171/CASE23338

PMCID: PMC10555560

PMID: 37728296

Files and links (1)

url

https://doi.org/10.3171/CASE23338View

Published (Version of record) Open Access

Abstract

BACKGROUND Malignant triton tumors (MTTs) are a rare and aggressive type of malignant peripheral nerve sheath tumor identified histologically by focal rhabdomyoblastic differentiation. OBSERVATIONS A 37-year-old female with a prior history of Hodgkin lymphoma presented with acute-onset confusion, cognitive deficits, and weakness. Brain magnetic resonance imaging revealed a hemorrhagic intracranial mass later confirmed to be a malignant triton tumor. The patient underwent two resections and several courses of chemoradiation for multiple tumor recurrences and metastases. Unfortunately, despite extensive treatment, she died 2 years after initial presentation from complications of this tumor. Her overall survival (OS) of 26.7 months was double that reported in historical cohorts (OS ∼13 mos). LESSONS The diagnosis and treatment of central nervous system MTTs are difficult and require a multidisciplinary team of neurosurgeons, radiologists, and oncologists. Histopathological analysis is required for confirmation of diagnosis. Gross-total resection of tumor and adjuvant radiation therapy have been shown to give patients the highest rates of survival and improved outcomes. Further studies and clinical trials are warranted to investigate the efficacy of chemotherapeutic agents like temozolomide, bevacizumab, and abemaciclib.

Details

Title: Subtitle: Clinical diagnostic and radiographic features of recurrent intracranial malignant triton tumor in an adult: illustrative case
Creators: Ajmain Chowdhury - University of Iowa
Alex Belzer - Carver College of Medicine, University of Iowa, Iowa City, Iowa
Nahom Teferi - Departments of Neurosurgery
Hend Al-Kaylani - University of Iowa
Juan Vivanco-Suarez - Departments of Neurosurgery
Assim Saad Eddin - Radiology
Kathryn Eschbacher - Pathology, and
Mohammed Milhem - University of Iowa
Patrick Hitchon - Departments of Neurosurgery
Resource Type: Journal article
Publication Details: Journal of Neurosurgery: Case Lessons, Vol.6(8), CASE23338
DOI: 10.3171/CASE23338
PMID: 37728296
PMCID: PMC10555560
NLM abbreviation: J Neurosurg Case Lessons
ISSN: 2694-1902
eISSN: 2694-1902
Language: English
Date published: 08/21/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Orthopedics and Rehabilitation; Neurosurgery; Internal Medicine
Record Identifier: 9984459416202771

Metrics

159 Record Views

See more details