Journal article
Clinical evaluation of ketorolac tromethamine 0.5% ophthalmic solution for the treatment of seasonal allergic conjunctivitis
Survey of ophthalmology, Vol.38(2), pp.141-148
1993
DOI: 10.1016/0039-6257(93)90038-9
PMID: 8236005
Abstract
We evaluated 148 patients with allergic conjunctivitis in a double-masked, paired comparison clinical trial comparing ketorolac 0.5% ophthalmic solution with vehicle. Patients received one drop of each study medication in preassigned eyes, four times a day, for seven days. Both treatments showed significant changes from baseline in the signs and symptoms associated with allergic conjunctivitis. Evaluations at the final visit (day 7 or 8) showed that ketorolac-treated eyes had a significant treatment response when compared to vehicle-treated eyes for conjunctival inflammation (p = 0.010), ocular itching (p = 0.006), swollen eyes (p = 0.002), discharge/tearing (p = 0.021), foreign body sensation (p = 0.035), and conjunctival injection (p = 0.016). Mean scores evaluating the overall therapeutic effect of the study treatments at the completion of the study were higher for ketorolac-treated eyes than for vehicle-treated eyes as rated by investigators (p = 0.004) and study patients (p < 0.001). Results of this study confirmed the trends of a previous study showing that ketorolac 0.5% ophthalmic solution applied topically is an effective therapy for allergic conjunctivitis.
Details
- Title: Subtitle
- Clinical evaluation of ketorolac tromethamine 0.5% ophthalmic solution for the treatment of seasonal allergic conjunctivitis
- Creators
- Zuhair Ballas - Division of Allergy and Immunology, University of Iowa, Iowa City, Iowa USAMalcolm Blumenthal - Section of Allergy, University of Minnesota Health Center, Minneapolis, Minnesota USADavid G Tinkelman - Department of Pediatrics, Medical College of Georgia, Augusta, Georgia USARobert Kriz - Department of Internal Medicine, University of Wisconsin, Madison, Wisconsin USAGary Rupp - Department of Pediatrics, Ohio State University, Columbus, Ohio USA
- Resource Type
- Journal article
- Publication Details
- Survey of ophthalmology, Vol.38(2), pp.141-148
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0039-6257(93)90038-9
- PMID
- 8236005
- ISSN
- 0039-6257
- eISSN
- 1879-3304
- Language
- English
- Date published
- 1993
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094747202771
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