Journal article
Clinical evaluation of the Prismaflex (TM) HF 20 set and Prismaflex (TM) system 7.10 for acute continuous kidney replacement therapy (CKRT) in children
Pediatric nephrology (Berlin, West), Vol.35(12), pp.2345-2352
12/01/2020
DOI: 10.1007/s00467-020-04664-7
PMID: 32607769
Abstract
Background Continuous kidney replacement therapy (CKRT) is a common modality for treatment of severe acute kidney injury (AKI) in children. Adult technologies routinely utilized to provide this therapy have a large extracorporeal volume. The Prismaflex (TM) HF20 filter set has a relatively low extracorporeal blood volume of 60 mL, which provides technological benefit for smaller children compared with current filter sets available in the USA.
Methods We conducted a multicenter, open-label single group study to evaluate whether the Prismaflex (TM) HF20 filter set delivers efficacious and safe CKRT to support patients with AKI, fluid overload, or both in pediatric patients weighing >= 8 to 20 kg.
Results Twenty-three patients were enrolled between April 24, 2016 and April 8, 2018. The mean reduction in blood urea nitrogen from baseline to 24 h was 58.12 +/- 20.08% (95% CI, - 68.45 and - 47.79 (p = 0.0008)). Median cumulative normalized effluent rate at 24 h was 60.8 mL/kg/h (25.9, 83.7). None of the patients participating in the study suffered a serious adverse event: thus, no obvious safety concerns were noted.
Conclusions We suggest that the Prismaflex HF20 (TM) filter set used in conjunction with the Prismaflex (TM) System Software Version 7.10 or 7.20 is a suitable alternative to larger filter sets for use in pediatric patients weighing less than 20 kg.
Details
- Title: Subtitle
- Clinical evaluation of the Prismaflex (TM) HF 20 set and Prismaflex (TM) system 7.10 for acute continuous kidney replacement therapy (CKRT) in children
- Creators
- Raj Munshi - Seattle Children'sKathy Lee-Son - University of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.Richard M. Hackbarth - Helen DeVos Children's HospitalRaymond Quigley - The University of Texas Southwestern Medical CenterScott M. Sutherland - Stanford UniversityJorge Echeverri - BaxterStuart L. Goldstein - University of Cincinnati Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.35(12), pp.2345-2352
- Publisher
- Springer Nature
- DOI
- 10.1007/s00467-020-04664-7
- PMID
- 32607769
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Number of pages
- 8
- Grant note
- DOI: 10.13039/100007658, name: Baxter Healthcare Corporation
- Language
- English
- Date published
- 12/01/2020
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984354040502771
Metrics
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