Journal article
Clinical experience with adaptive MRI-guided pancreatic SBRT and the use of abdominal compression to reduce treatment volume
Frontiers in oncology, Vol.14, 1441227
08/09/2024
DOI: 10.3389/fonc.2024.1441227
PMCID: PMC11341468
PMID: 39184046
Abstract
Introduction This work presents a method to treat stereotactic body radiation therapy (SBRT) for pancreatic cancer on a magnetic resonance-guided linear accelerator (MR-linac) using daily adaptation, real-time motion monitoring, and abdominal compression. Methods The motion management and treatment planning process involves a magnetic resonance imaging (MRI) simulation with cine and 3D images, a computed tomography (CT) simulation with a breath-hold CT and a 4DCT, pre-treatment verification and planning MRI, and intrafraction MRI cine images. Results The results from 26 patients were included in this work. Our motion management process results in consistent motion analysis on the CT simulation, MRI simulation, and each treatment fraction. The liver dome was found to be an overestimate of tumor superior/inferior (SI) motion for most patients. Adding compression reduced SI liver dome motion by 6.2 mm on average. Clinical outcomes are similar to those observed in the literature. Conclusions In this work, we demonstrate how pancreatic SBRT can be successfully treated on an MR-linac using abdominal compression. This allows for an increased duty cycle compared to gating and/or breath-hold techniques.
Details
- Title: Subtitle
- Clinical experience with adaptive MRI-guided pancreatic SBRT and the use of abdominal compression to reduce treatment volume
- Creators
- William S. FerrisBenjamin GeorgeKristin A. PlichtaJoseph M. CasterDaniel E. HyerBlake R. SmithJoel J. St-Aubin
- Resource Type
- Journal article
- Publication Details
- Frontiers in oncology, Vol.14, 1441227
- Publisher
- FRONTIERS MEDIA SA
- DOI
- 10.3389/fonc.2024.1441227
- PMID
- 39184046
- PMCID
- PMC11341468
- ISSN
- 2234-943X
- eISSN
- 2234-943X
- Grant note
DAS:The datasets presented in this article are not readily available because of the waiver of consent. Requests to access the datasets should be directed to JS-A (joel-st-aubin@uiowa.edu).
- Language
- English
- Date published
- 08/09/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984696863202771
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