Journal article
Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veterans
Digestive diseases and sciences, Vol.52(2), pp.570-578
02/2007
DOI: 10.1007/s10620-006-9418-4
PMID: 17226072
Abstract
Studies have indicated a high prevalence of hepatic steatosis in patients with chronic hepatitis C (CHC). To address the impact of steatosis on the clinical course of CHC and treatment response requires large multicenter studies. The present study analyzed hepatitis C virus (HCV)-infected veterans enrolled in a U.S. Veteran Administration multicenter study of the epidemiology and response to interferon alpha-2b and ribavirin treatment. Of the 357 patients, 97.1% were males, with a mean age of 48.7+/-6.4 years, and 184 (51.5%) had hepatic steatosis. The mean body mass index (BMI) was 29.3+/-5.2 kg/m(2), including 37.1% who were obese (BMI, > or =30 kg/m(2)). Stage III-IV fibrosis was present in 111 of 334 (33.3%) of the patients. After adjusting for age, race, and history of alcohol use in the past 12 months, only stage III-IV fibrosis was independently and significantly associated with hepatic steatosis (P=0.03). There was a trend of association between obesity and steatosis independent of the other factors. Only HCV genotype was independently associated with a sustained virological response (SVR) to interferon alpha-2b and ribavirin treatment after adjusting for age, alcohol use, steatosis, BMI, stage III-IV fibrosis, serum AFP, and HCV load. In conclusion, analyses of our multicenter trial data demonstrated that the prevalence of hepatic steatosis is 51.5% in HCV-infected U.S. veterans. We found that steatosis is independently associated with stage III-IV fibrosis. However, only HCV genotype, and not steatosis, obesity, or stage III-IV fibrosis, was associated with SVR to interferon alpha-2b and ribavirin treatment.
Details
- Title: Subtitle
- Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veterans
- Creators
- Ke-Qin Hu - Loma Linda VA Medical Center, Loma Linda, CA, USA. kqhu@uci.eduSue L CurrieHui ShenRamsey C CheungSamuel B HoEdmund J BiniJohn D McCrackenTim MorganNorbert BräuWarren N SchmidtLennox JeffersTeresa L WrightVA HCV-001 Study Group
- Resource Type
- Journal article
- Publication Details
- Digestive diseases and sciences, Vol.52(2), pp.570-578
- DOI
- 10.1007/s10620-006-9418-4
- PMID
- 17226072
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- Language
- English
- Date published
- 02/2007
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094317802771
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