Clinical predictors of driving status in Huntington's disease

Leigh J Beglinger; Luke Prest; James A Mills; Jane S Paulsen; Megan M Smith; Pedro Gonzalez-Alegre; Kelly C Rowe; Peggy Nopoulos; Ergun Y Uc

doi:10.1002/mds.25101

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Clinical predictors of driving status in Huntington's disease

Journal article

Open access

Peer reviewed

Clinical predictors of driving status in Huntington's disease

Leigh J Beglinger, Luke Prest, James A Mills, Jane S Paulsen, Megan M Smith, Pedro Gonzalez-Alegre, Kelly C Rowe, Peggy Nopoulos and Ergun Y Uc

Movement disorders, Vol.27(9), pp.1146-1152

08/2012

DOI: 10.1002/mds.25101

PMCID: PMC3638899

PMID: 22744778

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https://www.ncbi.nlm.nih.gov/pmc/articles/3638899View

Open Access

Abstract

The aim of this study was to identify the motor, cognitive, and behavioral determinants of driving status and risk factors for driving cessation in Huntington's disease (HD). Seventy-four patients with HD were evaluated for cognitive, motor, psychiatric, and functional status using a standardized battery (Unified Huntington's Disease Rating Scale [UHDRS] and supplemental neuropsychological testing) during a research clinic visit. Chart review was used to categorize patients into two driving status categories: (1) "currently driving" included those driving and driving but with clinician recommendation to restrict, and (2) "not driving" included those with clinician recommendation to cease driving and those not currently driving because of HD. Multi- and univariate logistic regression was used to identify significant clinical predictors of those driving versus not driving. Global cognitive performance and UHDRS Total Functional Capacity scores provided the best predictive model of driving cessation (Nagelkerke R(2) = 0.65; P < 0.0001). Measures of learning (P = 0.006) and psychomotor speed/attention (P = 0.003) accounted for the overall cognitive finding. In univariate analyses, numerous cognitive, motor, and daily functioning items were significantly associated with driving. Although driving status is associated with many aspects of the disease, results suggest that the strongest association is with cognitive performance. A detailed cognitive evaluation is an important component of multidisciplinary clinical assessment in patients with HD who are driving.

Psychomotor Performance

Data Interpretation, Statistical

Humans

Middle Aged

Risk Factors

Attention

Huntington Disease - psychology

Male

Automobile Driving - psychology

Disease Progression

Learning

Neuropsychological Tests

Regression Analysis

Neurologic Examination

Cognition Disorders - etiology

Mental Status Schedule

Adult

Female

Aged

Motor Skills

Cognition Disorders - psychology

Details

Title: Subtitle: Clinical predictors of driving status in Huntington's disease
Creators: Leigh J Beglinger - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. leigh-beglinger@uiowa.edu
Luke Prest
James A Mills
Jane S Paulsen
Megan M Smith
Pedro Gonzalez-Alegre
Kelly C Rowe
Peggy Nopoulos
Ergun Y Uc
Resource Type: Journal article
Publication Details: Movement disorders, Vol.27(9), pp.1146-1152
DOI: 10.1002/mds.25101
PMID: 22744778
PMCID: PMC3638899
NLM abbreviation: Mov Disord
ISSN: 0885-3185
eISSN: 1531-8257
Publisher: United States
Grant note: NS040068 / NINDS NIH HHS R01 NS040068 / NINDS NIH HHS Intramural NIH HHS K23 NS055733 / NINDS NIH HHS R01 AG030417 / NIA NIH HHS
Language: English
Date published: 08/2012
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984004182602771

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