Journal article
Clinical response to nitroglycerin as a diagnostic test for coronary artery disease
The American journal of cardiology, Vol.29(2), pp.149-153
01/01/1972
DOI: 10.1016/0002-9149(72)90623-6
PMID: 4621671
Abstract
The clinical response to nitroglycerin was correlated with the results of coronary angiography in 70 patients with chest pain of the anginal type: 49 patients with coronary artery disease and 21 without demonstrable cardiac disease. Of the patients with coronary disease, 76 percent were regularly relieved of pain in 3 minutes or less; 16 percent required more than 3 minutes for relief; and 8 percent were not relieved by the drug. Of the patients without coronary disease, only 19 percent consistently obtained relief in 3 minutes or less. Patients with coronary disease whose response to nitroglycerin was delayed or absent tended to have more frequent and intense pain, more coronary arteries involved by obstructive lesions and more hemodynamic or wall motion abnormalities than those who had prompt relief. Severe or bizarre side effects were common in patients without coronary disease but rare in patients with disease. It is concluded that 90 percent of patients with recurrent, angina-like chest pain who exhibit a prompt response to nitroglycerin have coronary artery disease; a delayed or absent response paradoxically indicates either absence of coronary artery disease or unusually severe disease and angina.
Details
- Title: Subtitle
- Clinical response to nitroglycerin as a diagnostic test for coronary artery disease
- Creators
- Lawrence D. HorwitzMichael V. HermanRichard Gorlin
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.29(2), pp.149-153
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0002-9149(72)90623-6
- PMID
- 4621671
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Language
- English
- Date published
- 01/01/1972
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656606202771
Metrics
5 Record Views