Journal article
Clinical significance of putative cancer stem cell marker CD44 in different histological subtypes of lung cancer
Cancer biomarkers : section A of Disease markers, Vol.14(6), pp.457-467
01/01/2014
DOI: 10.3233/CBM-140424
PMID: 25335738
Abstract
BACKGROUND: According to the cancer stem cell theory, tumors originate from a subset of cells known as cancer stem cells (CSCs) that are responsible for tumor initiation, resistance and relapse. CD44 is a cell adhesion molecule that can aid in the identification of CSCs in various malignancies.
OBJECTIVE: The purpose of the current study is to evaluate the expression level and clinical significance of CD44 in lung cancer samples.
METHODS: One hundred and ninety-five lung tumor samples including 74 (38%) squamous cell carcinomas (SCC), 61 (31%) adenocarcinomas (ADC), 23 (12%) large cell carcinoma (LCC) in non-small cell lung cancer (NSCLC) group and 37 (19%) small cell lung cancer (SCLC) samples were examined for the expression of CD44 using immunohistochemistry method. The correlation of CD44 expression with clinicopathological parameters as well as Ki-67 status was also assessed.
RESULTS: Univariate analysis demonstrated that CD44 expression was significantly higher in NSCLC compared to SCLC (P < 0.001). Among NSCLC, higher level of CD44 expression was found in SCC compared to ADC (P < 0.001) and LCC (P = 0.046). Increased expression of CD44 was significantly correlated with higher grade tumors which correspond to poor prognosis in SCC (P = 0.012) and the lower level of CD44 expression was more often found in well differentiated ADC tumors (P = 0.03). In addition, high expression of CD44 was significantly associated with decreased level of proliferative marker Ki-67 (P = 0.04).
CONCLUSIONS: CD44 could be a valuable tool for the study of lung CSCs and provide a novel therapeutic target for treatment of the patients with lung cancer in combination with conventional therapy.
Details
- Title: Subtitle
- Clinical significance of putative cancer stem cell marker CD44 in different histological subtypes of lung cancer
- Creators
- Raheleh Roudi - Iran University of Medical SciencesZahra Madjd - Iran University of Medical SciencesAlireza Korourian - Iran University of Medical SciencesMitra Mehrazma - Iran University of Medical SciencesSaadat Molanae - Milad HospitalMehrdad Nasrollahzadeh Sabet - Iran University of Medical SciencesAhmad Shariftabrizi - Tufts University
- Resource Type
- Journal article
- Publication Details
- Cancer biomarkers : section A of Disease markers, Vol.14(6), pp.457-467
- Publisher
- Ios Press
- DOI
- 10.3233/CBM-140424
- PMID
- 25335738
- ISSN
- 1574-0153
- eISSN
- 1875-8592
- Number of pages
- 11
- Grant note
- 15998 / Iran University of Medical Sciences
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Radiology
- Record Identifier
- 9984318686702771
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