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Clinical significance of the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase
Journal article

Clinical significance of the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase

David S Jacobs, Robert A Robinson, Gary M Clark and Jerald M Tucker
Annals of clinical and laboratory science, Vol.7(5), pp.411-421
09/1977
PMID: 900865

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Abstract

Five hundred patients with the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase (LDH) were surveyed. The isomorphic pattern of LDH isoenzymes is defined as a significant increase of total LDH with normal or low percentage of individual fractions, but with the LDH1:2 ratio less than unity. Diagnoses were, in descending order of frequency, cardiorespiratory diseases, malignancy, fracture, diseases of the central nervous system, infection/inflammation, hepatic cirrhosis and/or alcoholism, trauma without fracture, infectious mononucleosis, hypothyroidism, uremia, necrosis, pseudomononucleosis, viremia and intestinal obstruction. Incidence of increased serum activity in individuals without evidence of disease or drug explanation was 3 percent. Low PaO2 was observed in 88 percent of the 67 patients in whom it was measured.
Uremia - enzymology Isoenzymes Humans Middle Aged Neoplasms - enzymology Brain Diseases - enzymology Male False Positive Reactions Heart Diseases - enzymology Liver Cirrhosis - enzymology Isomerism Alcoholism - enzymology Infectious Mononucleosis - enzymology Polycythemia - enzymology L-Lactate Dehydrogenase - blood Lung Diseases, Obstructive - enzymology Adolescent Adult Female Hypothyroidism - enzymology Aged Wounds and Injuries - enzymology Necrosis - enzymology

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