Journal article
Clinical trial knowledge, discussion, and participation among cancer survivors: A HINTS-SEER study
Patient education and counseling, Vol.132, 108605
03/2025
DOI: 10.1016/j.pec.2024.108605
PMCID: PMC12754847
PMID: 39675132
Abstract
Clinical trial knowledge and discussions about clinical trials with healthcare providers contribute to clinical trial participation and clinical trial representation. This study explored 1) the association of patient-provider communication with clinical trial knowledge, 2) how patient-provider communication impacts the associations of demographic and clinical factors with clinical trial knowledge, and 3) motivations for clinical trial participation among people with a history of cancer.
Cross-sectional data from the 2021 Health Information National Trends Survey-Surveillance, Epidemiology, and End Results (HINTS-SEER) study included 1201 adult cancer survivors recruited from three SEER registries. Multivariable logistic regression models estimated adjusted associations of sociodemographic and clinical characteristics with clinical trial knowledge (none, a little bit/a lot) with and without the inclusion of clinical trial discussion with a healthcare provider (yes, no).
Approximately three-quarters of cancer survivors reported having at least “a little” knowledge about clinical trials, though only 15 % reported having discussed clinical trials with their provider. Those who reported patient-provider communication about clinical trials had 8.71 times higher odds of having some clinical trial knowledge. In multivariable logistic regression, odds of knowing at least a little bit about clinical trials were lower among adults without a college degree and among Hispanic and Non-Hispanic Asian (versus Non-Hispanic White) adults. Associations of demographic factors with clinical trial knowledge were not impacted by the inclusion of patient-provider discussion in the model. Top motivations for clinical trial participation were helping other people, new treatment, and getting better.
There is a need to ensure information about clinical trials is provided to all people with cancer and to facilitate high quality communication between patients and providers about clinical trials.
•78 % of cancer survivors reported at least a little knowledge about clinical trials.; Only 15 % reported discussing trials with a healthcare provider.•Patient-provider communication about clinical trials was associated with 8.71 times higher odds of clinical trial knowledge.•Odds of knowing about clinical trials were lower among adults without a college degree and Hispanic and Non-Hispanic Asian adults.•Top motivations for clinical trial participation were helping other people, new treatment, and getting better.•Knowledge of clinical trials differs across cancer survivors’ sociodemographic characteristics.
Details
- Title: Subtitle
- Clinical trial knowledge, discussion, and participation among cancer survivors: A HINTS-SEER study
- Creators
- Erin O. Wissler Gerdes - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USASarah H. Nash - University of IowaRobin C. Vanderpool - National Cancer InstituteErin L. Van Blarigan - University of California, San FranciscoAngela L.W. Meisner - University of New MexicoNicole Senft Everson - National Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Patient education and counseling, Vol.132, 108605
- DOI
- 10.1016/j.pec.2024.108605
- PMID
- 39675132
- PMCID
- PMC12754847
- NLM abbreviation
- Patient Educ Couns
- ISSN
- 0738-3991
- eISSN
- 1873-5134
- Publisher
- Elsevier B.V
- Grant note
- EWG: U01CA258400 State Health Registry of Iowa: HHSN26120130010I Greater Bay Area Cancer Registry: HHSN261201800032I New Mexico Tumor Registry (NCI): HHSN261201800014I NCI's Surveillance, Epidemiology and End Results ProgramCalifornia Department of Public Health pursuant to California Health and Safety: 103885 Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries: 1NU58DP007156 National Cancer Institute's Surveillance, Epidemiology and End Results Program: HHSN261201800032I University of California, San Francisco: HHSN261201800015I University of Southern California: HHSN261201800009I
EWG is supported by U01CA258400. The State Health Registry of Iowa (Contract HHSN26120130010I) , the Greater Bay Area Cancer Registry (Contract HHSN261201800032I) , and the New Mexico Tumor Registry (NCI Contract HHSN261201800014I) are supported by the NCI's Surveillance, Epidemiology and End Results Program. The collection of cancer incidence data used in this study was supported by the California Department of Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries, under Cooperative agreement 1NU58DP007156; the National Cancer Institute's Surveillance, Epidemiology and End Results Program under contract HHSN261201800032I awarded to the University of California, San Francisco, contract HHSN261201800015I awarded to the University of Southern California, and contract HHSN261201800009I awarded to the Public Health Institute, Cancer Registry of Greater California.
- Language
- English
- Date published
- 03/2025
- Academic Unit
- Epidemiology; Center for Social Science Innovation; Community and Behavioral Health
- Record Identifier
- 9984757198902771
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