Journal article
Clinically important improvement in function is common in people with or at high risk of knee OA: the MOST study
Journal of rheumatology, Vol.37(6), pp.1244-1251
06/2010
DOI: 10.3899/jrheum.090989
PMCID: PMC2913686
PMID: 20395640
Abstract
To calculate the frequency of clinically important improvement in function over 30 months and identify risk factors in people who have or are at risk of knee osteoarthritis (OA).
Subjects were from the Multicenter Osteoarthritis (MOST), a longitudinal study of persons with or at high risk of knee OA. We defined minimal clinically important improvement (MCII) with the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) physical function using 3 different methods. Baseline risk factors tested for improvement included age, sex, educational attainment, presence of radiographic knee OA (ROA), the number of comorbidities, body mass index (BMI), knee pain, walking speed, isokinetic knee extensor strength, depressive symptoms, physical activity, and medication usage. We used logistic regression to evaluate the association of baseline risk factors with MCII.
Of the 1801 subjects (mean age 63 yrs, BMI = 31, 63% women), most had mild limitations in baseline function (WOMAC = 19 +/- 11). Regardless of how defined, a substantial percentage of subjects (24%-39%) reached MCII at 30 months. Compared to their counterparts, people with MCII were less likely to have ROA and to use medications, and were more likely to have a lower BMI, less knee pain, a faster walking speed, more knee strength, and fewer depressive symptoms. After adjustment, MCII was 40% to 50% less likely in those with ROA, and 1.9 to 2.0 times more likely in those walking 1.0 meters/second faster than counterparts.
Clinically important improvement is frequent in people with or at high risk of knee OA. The absence of ROA and a faster walking speed appear to be associated with clinically important improvements.
Details
- Title: Subtitle
- Clinically important improvement in function is common in people with or at high risk of knee OA: the MOST study
- Creators
- Daniel K White - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street X 200, Boston, MA 02118, USA. white.daniel@gmail.comJulie J KeysorMichael P LavalleyCora E LewisJames C TornerMichael C NevittDavid T Felson
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.37(6), pp.1244-1251
- DOI
- 10.3899/jrheum.090989
- PMID
- 20395640
- PMCID
- PMC2913686
- NLM abbreviation
- J Rheumatol
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Publisher
- Canada
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG019069-01A1 / NIA NIH HHS U01 AG018832 / NIA NIH HHS AR47785 / NIAMS NIH HHS AR007598 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01 AG18820 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS T32 AR007598-07 / NIAMS NIH HHS U01 AG018820-01A1 / NIA NIH HHS T32 AR007598 / NIAMS NIH HHS U01 AG018832-01A1 / NIA NIH HHS U01 AG 18947 / NIA NIH HHS P60 AR047785-01 / NIAMS NIH HHS U01 AG 19069 / NIA NIH HHS U01 AG018947-01A1 / NIA NIH HHS U01 AG 18832 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 06/2010
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995018302771
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