Clinicopathologic Characterization of Invasive Fungal Intestinal Infections in Pediatric Patients

Muhammad Shaheen; Guang-Sheng Lei; Ryan F Relich; Iván A González

doi:10.1177/10935266241272564

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Clinicopathologic Characterization of Invasive Fungal Intestinal Infections in Pediatric Patients

Journal article

Peer reviewed

Clinicopathologic Characterization of Invasive Fungal Intestinal Infections in Pediatric Patients

Muhammad Shaheen, Guang-Sheng Lei, Ryan F Relich and Iván A González

Pediatric and developmental pathology, Vol.27(6), pp.545-551

11/2024

DOI: 10.1177/10935266241272564

PMID: 39215520

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Abstract

Invasive fungal intestinal infections are rare in pediatric patients with limited studies reported to date. Retrospective study of invasive intestinal fungal infections in pediatric patients. For fungal specification, 18S rRNA gene PCR was performed using formalin-fixed paraffin-embedded tissues. A total of 19 cases from 18 patients were included (13 males, 72%) with a median age of 20 days (8 days-14 years). About 13 patients (72%) presented within 67 days of birth and 11 patients (61%) were premature and 14 patients (78%) had a significant medical history. The most common location was the jejunum/ileum (56%) followed by the right colon and terminal ileum (22%). In 10 patients, the fungal elements were seen in the mucosa with 3 extending into the submucosa, and only 3 patients showed full-thickness involvement. Tissue necrosis and angioinvasion were seen in 13 (72%) and 8 (44%) patients, respectively. Morphologically, organisms consistent with spp. were seen in 17 patients and with a mucoraceous mold in 1 patient. A 18S rRNA gene sequencing performed in 18 cases identified in 16 cases and spp. in 2 cases. During the study follow-up period, 56% of the patients died. In our experience, most cases were due to spp. and predominantly in premature infants and associated with poor outcomes.

Adolescent

Child

Child, Preschool

Female

Humans

Infant

Infant, Newborn

Intestinal Diseases - diagnosis

Intestinal Diseases - microbiology

Intestinal Diseases - pathology

Invasive Fungal Infections - diagnosis

Invasive Fungal Infections - microbiology

Invasive Fungal Infections - pathology

Male

Retrospective Studies

RNA, Ribosomal, 18S - genetics

Details

Title: Subtitle: Clinicopathologic Characterization of Invasive Fungal Intestinal Infections in Pediatric Patients
Creators: Muhammad Shaheen - Riley Hospital for Children
Guang-Sheng Lei - Indiana University School of Medicine
Ryan F Relich - Riley Hospital for Children
Iván A González - Riley Hospital for Children
Resource Type: Journal article
Publication Details: Pediatric and developmental pathology, Vol.27(6), pp.545-551
DOI: 10.1177/10935266241272564
PMID: 39215520
ISSN: 1093-5266
eISSN: 1615-5742
Language: English
Date published: 11/2024
Academic Unit: Pathology
Record Identifier: 9985217062402771

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