Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series

Michael R. Sargen; Madeline H. Fitzhugh; Jennifer S. Ko; Allison G. Close; Sara C. Horton; Faizan Malik; Larissa V. Furtado; Armita Bahrami; Brittani K. N. Seynnaeve; Alberto S. Pappo; Vincent Liu; Kevin Cheung; Svetlana D. Pack; Liqiang Xi; Mark Raffeld; Ina Lee; Jeffrey Gagan; Kenneth Aldape; Christina K. Ferrone; Frederic G. Barr; Anna Hayden; Stephen M. Hewitt; Jessica N. Hatton; Alisa M. Goldstein; Ruth M. Pfeiffer; Brigitte Widemann; Mary Frances Wedekind Malone; Andrea M. Gross; Rosandra Kaplan; Marielle E. Yohe; Kristen G. Berrebi

doi:10.1002/pbc.31814

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Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series

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Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series

Michael R. Sargen, Madeline H. Fitzhugh, Jennifer S. Ko, Allison G. Close, Sara C. Horton, Faizan Malik, Larissa V. Furtado, Armita Bahrami, Brittani K. N. Seynnaeve, Alberto S. Pappo, …

Pediatric blood & cancer, Vol.72(8), e31814

08/2025

DOI: 10.1002/pbc.31814

PMID: 40390195

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Abstract

Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) and MED15::ATF1 ‐rearranged tumors (MARTs). In this series of pediatric CTRTs ( n = 5) and MARTs ( n = 2), all tumors exhibited spitzoid morphology and expressed melanocytic markers. Metastatic progression occurred in one CTRT and two MARTs: all three received immunotherapy, resulting in disease control in two patients and one death due to progressive disease. A fourth individual had lymph node micrometastasis that remained stable without progression. This case series highlights the potentially aggressive behavior of these tumors and suggests that immunotherapy may be an effective treatment option for advanced disease.

Immunotherapy

<italic>CRTC1::TRIM11</italic> fusion

<italic>MED15::ATF1</italic> fusion

melanoma

Spitz

spitzoid

Details

Title: Subtitle: Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series
Creators: Michael R. Sargen - National Institutes of Health
Madeline H. Fitzhugh - University of Iowa
Jennifer S. Ko - Cleveland Clinic
Allison G. Close - Helen DeVos Children's Hospital
Sara C. Horton - University of Iowa
Faizan Malik - St. Jude Children's Research Hospital
Larissa V. Furtado - St. Jude Children's Research Hospital
Armita Bahrami - Emory University
Brittani K. N. Seynnaeve - University of Pittsburgh School of Medicine
Alberto S. Pappo - St. Jude Children's Research Hospital
Vincent Liu - University of Iowa
Kevin Cheung - Department of Dermatology University of Iowa Hospitals and Clinics Iowa City Iowa USA
Svetlana D. Pack - National Institutes of Health
Liqiang Xi - National Institutes of Health
Mark Raffeld - National Institutes of Health
Ina Lee - National Cancer Institute
Jeffrey Gagan - National Cancer Institute
Kenneth Aldape - National Institutes of Health
Christina K. Ferrone - National Cancer Institute
Frederic G. Barr - National Cancer Institute
Anna Hayden - University of Louisville
Stephen M. Hewitt - National Cancer Institute
Jessica N. Hatton - National Institutes of Health
Alisa M. Goldstein - National Cancer Institute
Ruth M. Pfeiffer - National Cancer Institute
Brigitte Widemann - National Cancer Institute
Mary Frances Wedekind Malone - National Institutes of Health
Andrea M. Gross - National Cancer Institute
Rosandra Kaplan - National Cancer Institute
Marielle E. Yohe - National Institutes of Health
Kristen G. Berrebi - University of Iowa
Resource Type: Journal article
Publication Details: Pediatric blood & cancer, Vol.72(8), e31814
DOI: 10.1002/pbc.31814
PMID: 40390195
NLM abbreviation: Pediatr Blood Cancer
ISSN: 1545-5009
eISSN: 1545-5017
Publisher: WILEY; HOBOKEN
Grant note: Intramural Research Program of the Division of Cancer Epidemiology and Genetics and the Center for Cancer Research
The authors have nothing to report.
Language: English
Electronic publication date: 05/19/2025
Date published: 08/2025
Academic Unit: Dermatology; Stead Family Department of Pediatrics; Pathology; Hematology/Oncology
Record Identifier: 9984824330502771

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