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Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion
Journal article   Open access   Peer reviewed

Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion

Jost B Jonas, Sohan S Hayreh and Yong Tao
Indian journal of ophthalmology, Vol.62(2), pp.219-223
02/2014
DOI: 10.4103/0301-4738.111216
PMCID: PMC4005240
PMID: 23619503
url
https://doi.org/10.4103/0301-4738.111216View
Published (Version of record) Open Access

Abstract

To investigate the clinicopathological correlation of parapapillary atrophy. The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary occlusion of the central retinal artery, and 1 normal eye. On histological sections, we measured zones with different histological characteristics.On fundus photographs, alpha zone and beta zone of parapapillary atrophy were measured and correlated with the histological data. The size of the clinical alpha zone of parapapillary atrophy was significantly correlated with the size of the histological region with irregularities of the retinal pigment epithelium (P = 0.05; correlation coefficient r = 0.49) and with the size of the histological region with a decreased density of retinal photoreceptors (P = 0.01; r = 0.60). The size of clinical beta zone of parapapillary atrophy significantly correlated with the size of the histological region with complete loss of the retinal pigment epithelium (P <0.001; r = 0.91), with the size of the histological zone with a complete loss of photoreceptors (P <0.001; r = 0.81), and with the size of the histological zone with a closed choriocapillaris (P <0.001; r = 0.89). The clinically seen alpha zone of parapapillary atrophy correlates with histological parapapillary irregularities of the retinal pigment epithelium and decreased density of retinal photoreceptors. The clinically seen beta zone of parapapillary atrophy correlates with histological complete loss of the retinal pigment epithelium and of the photoreceptors, and a closure of the choriocapillaris.
 Atrophy Retinal Pigment Epithelium - pathology Animals Retinal Artery Occlusion - pathology Follow-Up Studies Ophthalmoscopy Glaucoma, Open-Angle - pathology Macaca mulatta Photomicrography Disease Progression Disease Models, Animal

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