Journal article
Cloning and Expression of a Novel Human Brain Na Channel
The Journal of biological chemistry, Vol.271(14), pp.7879-7882
04/05/1996
DOI: 10.1074/jbc.271.14.7879
PMID: 8626462
Abstract
We have cloned a novel cDNA from human brain which encodes a non-voltage-dependent Na+ channel (BNC1). BNC1 has some sequence similarity (24-28%) with a new channel family that includes subunits of the mammalian epithelial Na+ channel, the Caenorhabditis elegans degenerins, and the Helix aspersa FMRF-amide-gated Na+ channel. Like other family members it is inhibited by amiloride. However, its predicted structure differs from other family members, its discrimination between Na+ and Li+ is different, and in contrast to other mammalian family members, coexpression with other cloned subunits of the family does not increase current. BNC1 has a unique pattern of expression with transcripts detected only in adult human brain and in spinal cord. Thus, BNC1 is the first cloned member of a new subfamily of mammalian Na+ channels. The function of BNC1 as a non-voltage-gated Na+ channel in human brain suggests it may play a novel role in neurotransmission.
Details
- Title: Subtitle
- Cloning and Expression of a Novel Human Brain Na Channel
- Creators
- Margaret P PricePeter M SnyderMichael J Welsh
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.271(14), pp.7879-7882
- DOI
- 10.1074/jbc.271.14.7879
- PMID
- 8626462
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Language
- English
- Date published
- 04/05/1996
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Cardiovascular Medicine; Neurosurgery; Medicine Administration; Internal Medicine
- Record Identifier
- 9984020744702771
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