Journal article
Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A
FEBS letters, Vol.460(3), pp.462-466
1999
DOI: 10.1016/S0014-5793(99)01377-0
PMID: 10556517
Abstract
Variable regulatory subunits of protein phosphatase 2A (PP2A) modulate activity, substrate selectivity and subcellular targeting of the enzyme. We have cloned a novel member of the B type regulatory subunit family, Bδ, which is most highly related to Bα. Bδ shares with Bα epitopes previously used to generate subunit-specific antibodies. Like Bα, but unlike Bβ and Bγ which are highly brain-enriched, Bδ mRNA and protein expression in tissues is widespread. Bδ is a cytosolic subunit of PP2A with a subcellular localization different from Bα and may therefore target a pool of PP2A holoenzymes to specific substrates.
Details
- Title: Subtitle
- Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A
- Creators
- Stefan Strack - Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USADennis Chang - Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USAJulie A Zaucha - Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USARoger J Colbran - Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USABrian E Wadzinski - Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.460(3), pp.462-466
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0014-5793(99)01377-0
- PMID
- 10556517
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Language
- English
- Date published
- 1999
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040305502771
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