Journal article
Cloning and developmental expression of the soxB2 genes, sox14 and sox21, during Xenopus laevis embryogenesis
The International journal of developmental biology, Vol.52(7), pp.999-1004
2008
DOI: 10.1387/ijdb.082586dc
PMCID: PMC2587241
PMID: 18956331
Abstract
The Sox family of transcription factors is thought to regulate gene expression in a wide variety of developmental processes. Here we describe the cloning of the
X. laevis
orthologs of the SoxB2 family of transcription factors,
sox14
and
sox21. In situ
hybridization revealed that
sox14
expression is restricted to the hypothalamus, dorsal thalamus, the optic tectum, a region of the somatic motornucleus in the midbrain and hindbrain, the vestibular nuclei in the hindbrain and a discrete ventral domain in the developing spinal cord. In contrast to the limited expression domain of
sox14
,
sox21
is found throughout the developing central nervous system, including the olfactory placodes, with strongest expression at the boundary between the midbrain and hindbrain.
Details
- Title: Subtitle
- Cloning and developmental expression of the soxB2 genes, sox14 and sox21, during Xenopus laevis embryogenesis
- Creators
- DOREEN D CUNNINGHAM - Georgetown University, Department of Biology, Washington DCZHUO MENG - Georgetown University, Department of Biology, Washington DCBERND FRITZSCH - Creighton University, Department of Biomedical Sciences, Omaha, NE, USAELENA SILVA CASEY - Georgetown University, Department of Biology, Washington DC
- Resource Type
- Journal article
- Publication Details
- The International journal of developmental biology, Vol.52(7), pp.999-1004
- DOI
- 10.1387/ijdb.082586dc
- PMID
- 18956331
- PMCID
- PMC2587241
- NLM abbreviation
- Int J Dev Biol
- ISSN
- 0214-6282
- eISSN
- 1696-3547
- Language
- English
- Date published
- 2008
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070697502771
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