Journal article
Cloning and expression of Xenopus Lrp5 and Lrp6 genes
Mechanisms of development, Vol.117(1), pp.337-342
2002
DOI: 10.1016/S0925-4773(02)00205-8
PMID: 12204281
Abstract
LRP5 and LRP6 comprise a subfamily of lipoprotein-receptor related proteins that function as co-receptors for Wnt proteins. Mutation of human
LRP5 is responsible for osteoporosis-pseudoglioma syndrome and disruption of
Lrp6 in mice causes similar effects to mutation of several different Wnt genes. We have cloned
Xenopus homologues of
Lrp5 and
Lrp6 (
Xlrp5,
Xlrp6) and examined their expression during embryogenesis. Both genes are expressed maternally and ubiquitously through early development. At later stages,
Xlrp5 is found in the eye, forebrain, hindbrain, branchial arches and the tip of the tail bud.
Xlrp6 is expressed throughout the central nervous system, branchial arches, in the eye and otic vesicle. Both genes are also expressed at the intersomitic boundary. These results suggest roles for Wnt signaling via LRP proteins in these tissues.
Details
- Title: Subtitle
- Cloning and expression of Xenopus Lrp5 and Lrp6 genes
- Creators
- Douglas W HoustonChris Wylie
- Resource Type
- Journal article
- Publication Details
- Mechanisms of development, Vol.117(1), pp.337-342
- DOI
- 10.1016/S0925-4773(02)00205-8
- PMID
- 12204281
- NLM abbreviation
- Mech Dev
- ISSN
- 0925-4773
- eISSN
- 1872-6356
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 2002
- Academic Unit
- Biology
- Record Identifier
- 9983991964802771
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