Cloning, characterization, and mapping of the mouse homeobox gene Hmx1

Koh-Ichiro Yoshiura; Nancy J Leysens; Rebecca S Reiter; Jeffrey C Murray

doi:10.1006/geno.1998.5284

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Cloning, characterization, and mapping of the mouse homeobox gene Hmx1

Journal article

Peer reviewed

Cloning, characterization, and mapping of the mouse homeobox gene Hmx1

Koh-Ichiro Yoshiura, Nancy J Leysens, Rebecca S Reiter and Jeffrey C Murray

Genomics (San Diego, Calif.), Vol.50(1), pp.61-68

1998

DOI: 10.1006/geno.1998.5284

PMID: 9628823

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Abstract

Homeobox-containing genes play an important role in development, including positional specification of the body plan and organogenesis. We previously isolated the human HMX1 (H6) gene, a novel homeobox-containing gene of the HMX family, from a human embryonic craniofacial cDNA library. The closely related mouse genes Hmx3 (Nkx5.1) and Hmx2 (Nkx5.2) are in the same class as the HMX1 gene and are expressed in the craniofacial region of the developing embryo. To provide a resource for further characterization of the human HMX1 gene, we isolated the mouse Hmx1 genomic clone. We show here the mouse Hmx1 genomic sequence, its gene mapping, and its expression pattern in the developing mouse embryo. Evidence is presented showing that the three known Hmx genes in the mouse likely play complementary roles in the development of the second arch, retina, sympathetic nerve ganglia, and cranial neural ganglia. Hmx1 may play an important role in the development of craniofacial structures and may interact with Hoxa-2 and Dlx-2 in the second branchial arch. Copyright 1998 Academic Press.

Molecular Genetics

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Molecular and cellular biology

Genes. Genome

Details

Title: Subtitle: Cloning, characterization, and mapping of the mouse homeobox gene Hmx1
Creators: Koh-Ichiro Yoshiura - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Nancy J Leysens - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Rebecca S Reiter - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, United States
Jeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: Genomics (San Diego, Calif.), Vol.50(1), pp.61-68
DOI: 10.1006/geno.1998.5284
PMID: 9628823
NLM abbreviation: Genomics
ISSN: 0888-7543
eISSN: 1089-8646
Publisher: Elsevier; San Diego, CA
Language: English
Date published: 1998
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025597202771

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